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Atomistry » Magnesium » PDB 6t2c-6tfk » 6t5b | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 6t2c-6tfk » 6t5b » |
Magnesium in PDB 6t5b: KRASG12C Ligand ComplexProtein crystallography data
The structure of KRASG12C Ligand Complex, PDB code: 6t5b
was solved by
C.Phillips,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6t5b:
The structure of KRASG12C Ligand Complex also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the KRASG12C Ligand Complex
(pdb code 6t5b). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the KRASG12C Ligand Complex, PDB code: 6t5b: Magnesium binding site 1 out of 1 in 6t5bGo back to![]() ![]()
Magnesium binding site 1 out
of 1 in the KRASG12C Ligand Complex
![]() Mono view ![]() Stereo pair view
Reference:
J.G.Kettle,
S.K.Bagal,
S.Bickerton,
M.S.Bodnarchuk,
J.Breed,
R.J.Carbajo,
D.J.Cassar,
A.Chakraborty,
S.Cosulich,
I.Cumming,
M.Davies,
A.Eatherton,
L.Evans,
L.Feron,
S.Fillery,
E.S.Gleave,
F.W.Goldberg,
S.Harlfinger,
L.Hanson,
M.Howard,
R.Howells,
A.Jackson,
P.Kemmitt,
J.K.Kingston,
S.Lamont,
H.J.Lewis,
S.Li,
L.Liu,
D.Ogg,
C.Phillips,
R.Polanski,
G.Robb,
D.Robinson,
S.Ross,
J.M.Smith,
M.Tonge,
R.Whiteley,
J.Yang,
L.Zhang,
X.Zhao.
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant Gtpase KRASG12C. J.Med.Chem. 2020.
Page generated: Tue Oct 1 18:40:58 2024
ISSN: ISSN 0022-2623 PubMed: 32023060 DOI: 10.1021/ACS.JMEDCHEM.9B01720 |
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