Magnesium in PDB 6ta4: Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules

The binding sites of Magnesium atom in the Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules (pdb code 6ta4). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules, PDB code: 6ta4:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg502 b:0.5 occ:1.00 CD2 B:LEU68 1.7 0.8 1.0 CB B:GLN11 2.1 0.1 1.0 CG B:GLN11 2.3 0.1 1.0 OE1 B:GLN11 2.9 0.1 1.0 O1B B:G2P501 3.0 0.4 1.0 CD B:GLN11 3.0 0.1 1.0 O2G B:G2P501 3.1 0.4 1.0 CG B:LEU68 3.1 0.8 1.0 CA B:GLN11 3.4 0.1 1.0 C3A B:G2P501 3.5 0.4 1.0 PB B:G2P501 3.6 0.4 1.0 CB B:LEU68 3.8 0.8 1.0 CD1 B:LEU68 3.9 0.8 1.0 N B:GLN11 4.0 0.1 1.0 NE2 B:GLN11 4.3 0.1 1.0 O3B B:G2P501 4.4 0.4 1.0 PG B:G2P501 4.4 0.4 1.0 O1A B:G2P501 4.4 0.4 1.0 PA B:G2P501 4.5 0.4 1.0 C B:GLN11 4.5 0.1 1.0 OE1 B:GLU69 4.6 0.3 1.0 OE2 B:GLU69 4.8 0.3 1.0 O2A B:G2P501 4.9 0.4 1.0

Magnesium binding site 2 out of 3 in the Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg502 b:0.1 occ:1.00 O2B A:GTP501 1.9 0.1 1.0 O1G A:GTP501 2.1 0.1 1.0 PB A:GTP501 2.6 0.1 1.0 OE1 A:GLN11 2.7 62.0 1.0 CG A:GLN11 2.7 62.0 1.0 OE2 A:GLU71 2.8 0.4 1.0 PG A:GTP501 2.9 0.1 1.0 O3A A:GTP501 3.0 0.1 1.0 O3B A:GTP501 3.0 0.1 1.0 CD A:GLN11 3.1 62.0 1.0 O2G A:GTP501 3.4 0.1 1.0 N A:GLN11 3.5 62.0 1.0 CB A:GLN11 3.8 62.0 1.0 CD A:GLU71 3.9 0.4 1.0 PA A:GTP501 4.0 0.1 1.0 O2A A:GTP501 4.1 0.1 1.0 O1B A:GTP501 4.1 0.1 1.0 CA A:GLN11 4.2 62.0 1.0 O3G A:GTP501 4.3 0.1 1.0 O B:ASN247 4.4 96.3 1.0 O1A A:GTP501 4.4 0.1 1.0 NE2 A:GLN11 4.4 62.0 1.0 C A:GLY10 4.5 39.6 1.0 CA A:GLY10 4.5 39.6 1.0 CG A:GLU71 4.6 0.4 1.0 OE1 A:GLU71 4.7 0.4 1.0

Magnesium binding site 3 out of 3 in the Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Human Kinesin-5 Motor Domain in the Amppnp State Bound to Microtubules within 5.0Å range: probe atom residue distance (Å) B Occ K:Mg602 b:14.2 occ:1.00 O2B K:ANP601 2.1 15.1 1.0 N K:SER233 2.2 11.5 1.0 O3G K:ANP601 2.2 13.1 1.0 OD1 K:ASP265 2.7 15.9 1.0 CA K:SER232 2.8 13.4 1.0 C K:SER232 2.9 12.8 1.0 CA K:SER233 3.3 11.7 1.0 CB K:SER232 3.3 13.2 1.0 CG K:ASP265 3.4 13.5 1.0 PB K:ANP601 3.4 14.3 1.0 OD2 K:ASP265 3.5 11.8 1.0 O K:SER233 3.5 11.6 1.0 PG K:ANP601 3.5 17.2 1.0 CB K:SER233 3.6 10.0 1.0 CB K:THR112 3.7 11.0 1.0 OG K:SER233 3.8 11.0 1.0 C K:SER233 3.8 10.6 1.0 N3B K:ANP601 3.9 16.2 1.0 O K:TYR231 3.9 16.4 1.0 N K:SER232 4.0 16.2 1.0 CG2 K:THR112 4.1 8.8 1.0 O K:SER232 4.1 13.8 1.0 OG1 K:THR112 4.2 9.4 1.0 O1G K:ANP601 4.2 18.1 1.0 O1B K:ANP601 4.3 11.3 1.0 C K:TYR231 4.4 18.0 1.0 O1A K:ANP601 4.4 17.3 1.0 OG K:SER232 4.5 13.1 1.0 O3A K:ANP601 4.5 18.2 1.0 O2G K:ANP601 4.7 21.1 1.0 CB K:ASP265 4.7 11.3 1.0 PA K:ANP601 4.8 20.0 1.0 O K:LEU266 4.9 8.3 1.0 CA K:THR112 5.0 10.6 1.0

A.Pena, A.Sweeney, A.D.Cook, M.Topf, C.A.Moores. Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure 2020.
ISSN: ISSN 0969-2126
PubMed: 32084356
DOI: 10.1016/J.STR.2020.01.013