Magnesium in PDB 6tiw: Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2)

The structure of Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2) also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

The binding sites of Magnesium atom in the Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2) (pdb code 6tiw). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2), PDB code: 6tiw:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2) within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg502 b:0.5 occ:1.00 O1B B:G2P501 2.1 0.4 1.0 O2G B:G2P501 2.2 0.4 1.0 CB B:GLN11 2.4 0.1 1.0 PB B:G2P501 2.5 0.4 1.0 C3A B:G2P501 2.5 0.4 1.0 NE2 B:GLN11 2.9 0.1 1.0 CD1 B:LEU68 2.9 0.8 1.0 O3B B:G2P501 3.1 0.4 1.0 PG B:G2P501 3.2 0.4 1.0 N B:GLN11 3.2 0.1 1.0 CA B:GLN11 3.3 0.1 1.0 CB B:LEU68 3.5 0.8 1.0 CG B:LEU68 3.6 0.8 1.0 CG B:GLN11 3.6 0.1 1.0 CD B:GLN11 3.7 0.1 1.0 PA B:G2P501 3.8 0.4 1.0 O2B B:G2P501 3.9 0.4 1.0 O1G B:G2P501 4.1 0.4 1.0 O1A B:G2P501 4.2 0.4 1.0 O2A B:G2P501 4.3 0.4 1.0 O3G B:G2P501 4.3 0.4 1.0 C B:GLY10 4.3 0.6 1.0 C B:GLN11 4.6 0.1 1.0 OG1 B:THR143 4.7 0.2 1.0 OE1 B:GLN11 4.9 0.1 1.0 CA B:LEU68 4.9 0.8 1.0 O B:GLY10 4.9 0.6 1.0 CB B:THR143 4.9 0.2 1.0 CD2 B:LEU68 5.0 0.8 1.0

Magnesium binding site 2 out of 2 in the Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg502 b:0.1 occ:1.00 NE2 A:GLN11 2.0 62.0 1.0 O2B A:G2P501 2.1 0.1 1.0 O1G A:G2P501 2.1 0.1 1.0 OE1 A:GLU71 2.2 0.4 1.0 C3A A:G2P501 2.5 0.1 1.0 CG A:GLN11 2.6 62.0 1.0 PB A:G2P501 2.6 0.1 1.0 CD A:GLN11 2.7 62.0 1.0 CD A:GLU71 3.1 0.4 1.0 PG A:G2P501 3.1 0.1 1.0 O3B A:G2P501 3.2 0.1 1.0 OE2 A:GLU71 3.3 0.4 1.0 O2A A:G2P501 3.3 0.1 1.0 PA A:G2P501 3.5 0.1 1.0 CB A:GLN11 3.7 62.0 1.0 N A:GLN11 3.7 62.0 1.0 OE1 A:GLN11 3.8 62.0 1.0 O2G A:G2P501 3.9 0.1 1.0 O1A A:G2P501 4.0 0.1 1.0 OD1 A:ASP98 4.0 50.4 1.0 O1B A:G2P501 4.1 0.1 1.0 CA A:GLN11 4.3 62.0 1.0 OD2 A:ASP98 4.4 50.4 1.0 O3G A:G2P501 4.4 0.1 1.0 CG A:GLU71 4.5 0.4 1.0 CG A:ASP98 4.6 50.4 1.0 OG1 A:THR145 4.7 70.5 1.0 C A:GLY10 4.8 39.6 1.0 CA A:GLY10 4.9 39.6 1.0 O5' A:G2P501 4.9 0.1 1.0

A.Pena, A.Sweeney, A.D.Cook, M.Topf, C.A.Moores. Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure 2020.
ISSN: ISSN 0969-2126
PubMed: 32084356
DOI: 10.1016/J.STR.2020.01.013