Magnesium in PDB 6tse: Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C

Enzymatic activity of Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C

All present enzymatic activity of Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C:
2.7.10.2;

Protein crystallography data

The structure of Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C, PDB code: 6tse was solved by P.Brear, J.Wagstaff, M.Hyvonen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 57.19 / 1.41
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.070, 60.594, 57.846, 90.00, 98.65, 90.00
R / Rfree (%) 20.1 / 22.4

Other elements in 6tse:

The structure of Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C (pdb code 6tse). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C, PDB code: 6tse:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 6tse

Go back to Magnesium Binding Sites List in 6tse
Magnesium binding site 1 out of 2 in the Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg201

b:24.9
occ:1.00
 O A:HOH365 2.0 30.1 1.0
O A:HOH345 2.1 24.6 1.0
O A:HOH305 2.2 24.9 1.0
O A:HOH357 3.9 32.6 1.0
O A:GLY47 4.3 24.6 1.0
OE2 A:GLU7 4.3 27.5 1.0
OE1 A:GLU7 4.4 34.4 1.0
CD A:GLU7 4.8 36.8 1.0

Magnesium binding site 2 out of 2 in 6tse

Go back to Magnesium Binding Sites List in 6tse
Magnesium binding site 2 out of 2 in the Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg201

b:19.7
occ:1.00
 O B:HOH305 2.0 20.5 1.0
O B:HOH323 2.1 22.2 1.0
O B:HOH320 2.2 23.9 1.0
O B:HOH344 3.9 25.3 1.0
OE2 B:GLU7 4.2 23.1 1.0
OE1 B:GLU7 4.2 24.6 1.0
O B:GLY47 4.3 24.2 1.0
CD B:GLU7 4.6 23.5 1.0

Reference:

P.Brear, G.Fischer, M.May, T.Pantelejevs, R.Mathieu, M.Rossmann, J.Wagstaff, B.Blaszczyk, M.Hyvonen. Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C To Be Published.
Page generated: Mon Jan 25 15:12:49 2021

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