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Magnesium in PDB 6u7c: Human GRK2 in Complex with Gbetagamma Subunits and CCG258747

Enzymatic activity of Human GRK2 in Complex with Gbetagamma Subunits and CCG258747

All present enzymatic activity of Human GRK2 in Complex with Gbetagamma Subunits and CCG258747:
2.7.11.15;

Protein crystallography data

The structure of Human GRK2 in Complex with Gbetagamma Subunits and CCG258747, PDB code: 6u7c was solved by R.Bouley, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.90 / 2.44
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 60.633, 240.610, 214.576, 90.00, 90.00, 90.00
R / Rfree (%) 23.7 / 26.2

Other elements in 6u7c:

The structure of Human GRK2 in Complex with Gbetagamma Subunits and CCG258747 also contains other interesting chemical elements:

Fluorine (F) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Human GRK2 in Complex with Gbetagamma Subunits and CCG258747 (pdb code 6u7c). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human GRK2 in Complex with Gbetagamma Subunits and CCG258747, PDB code: 6u7c:

Magnesium binding site 1 out of 1 in 6u7c

Go back to Magnesium Binding Sites List in 6u7c
Magnesium binding site 1 out of 1 in the Human GRK2 in Complex with Gbetagamma Subunits and CCG258747


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human GRK2 in Complex with Gbetagamma Subunits and CCG258747 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg702

b:0.9
occ:1.00
O A:GLU360 2.2 0.3 1.0
O A:GLN363 2.5 0.5 1.0
O A:HIS348 2.8 0.6 1.0
O A:VAL366 2.8 0.6 1.0
O A:VAL361 2.9 0.6 1.0
CE2 A:TYR368 3.0 0.0 1.0
CD2 A:TYR368 3.2 0.1 1.0
C A:GLU360 3.3 0.6 1.0
CA A:VAL361 3.3 1.0 1.0
C A:VAL361 3.3 0.1 1.0
C A:GLN363 3.4 0.7 1.0
C A:HIS348 3.6 0.6 1.0
N A:VAL361 3.7 0.8 1.0
C A:VAL366 3.9 0.6 1.0
CA A:HIS348 3.9 0.3 1.0
CB A:VAL366 4.1 0.0 1.0
N A:VAL366 4.1 0.8 1.0
N A:GLN363 4.1 0.1 1.0
CA A:VAL366 4.2 0.3 1.0
N A:LYS364 4.2 0.9 1.0
CA A:GLN363 4.3 0.7 1.0
CZ A:TYR368 4.3 0.6 1.0
CA A:LYS364 4.4 0.4 1.0
N A:LEU362 4.4 0.5 1.0
O A:ALA349 4.5 0.3 1.0
CA A:GLU360 4.5 0.6 1.0
CB A:HIS348 4.6 0.7 1.0
CG A:TYR368 4.6 0.7 1.0
N A:ALA349 4.7 0.9 1.0
CB A:GLN363 4.7 0.5 1.0
CB A:VAL361 4.7 0.9 1.0
C A:LEU362 4.7 0.9 1.0
CG1 A:VAL366 4.7 0.5 1.0
C A:ALA349 4.8 0.6 1.0
OH A:TYR368 4.8 0.7 1.0
N A:GLY365 4.8 0.4 1.0
C A:LYS364 4.9 0.5 1.0

Reference:

R.A.Bouley, Z.Y.Weinberg, H.V.Waldschmidt, Y.C.Yen, S.D.Larsen, M.A.Puthenveedu, J.J.G.Tesmer. A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the Mu-Opioid Receptor. Mol.Pharmacol. 2020.
ISSN: ESSN 1521-0111
PubMed: 32234810
DOI: 10.1124/MOL.119.118661
Page generated: Tue Oct 1 20:51:00 2024

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