Magnesium in PDB 6uit: Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with Dctp

All present enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with Dctp:
2.7.7.49; 2.7.7.7; 3.1.26.13;

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with Dctp, PDB code: 6uit was solved by E.B.Lansdon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.09 / 2.81
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	167.525, 167.790, 102.294, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 25.6

The binding sites of Magnesium atom in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with Dctp (pdb code 6uit). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with Dctp, PDB code: 6uit:

Magnesium binding site 1 out of 1 in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with Dctp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with Dctp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg604 b:24.6 occ:1.00 OD2 A:ASP110 1.9 37.4 1.0 O A:VAL111 1.9 31.6 1.0 OD2 A:ASP185 2.1 32.0 1.0 O2G A:DCP601 2.2 34.2 1.0 O2A A:DCP601 2.3 33.1 1.0 O2B A:DCP601 2.5 31.6 1.0 CG A:ASP110 2.8 37.3 1.0 C A:VAL111 3.1 31.2 1.0 CG A:ASP185 3.2 29.2 1.0 OD1 A:ASP110 3.2 39.7 1.0 PG A:DCP601 3.5 39.4 1.0 PA A:DCP601 3.5 32.9 1.0 PB A:DCP601 3.5 33.3 1.0 N A:VAL111 3.5 29.4 1.0 O3B A:DCP601 3.6 31.6 1.0 O3A A:DCP601 3.7 31.5 1.0 OD1 A:ASP185 3.8 26.7 1.0 CA A:VAL111 3.8 31.0 1.0 NZ A:LYS220 3.9 38.4 1.0 CB A:ASP110 4.0 30.6 1.0 N A:GLY112 4.1 28.8 1.0 O3G A:DCP601 4.2 39.0 1.0 C A:ASP110 4.2 29.7 1.0 O5' A:DCP601 4.4 27.7 1.0 CB A:VAL111 4.4 29.3 1.0 CA A:GLY112 4.4 28.9 1.0 CB A:ASP185 4.4 25.4 1.0 C5' A:DCP601 4.4 29.3 1.0 CE A:LYS220 4.4 37.1 1.0 N A:ASP113 4.5 30.5 1.0 CA A:ASP110 4.6 32.1 1.0 O1G A:DCP601 4.6 42.0 1.0 O1A A:DCP601 4.6 34.1 1.0 C A:GLY112 4.7 32.8 1.0 CB A:ALA114 4.7 30.8 1.0 N A:ALA114 4.8 29.8 1.0 O1B A:DCP601 4.9 34.5 1.0 O A:ASP110 4.9 32.4 1.0

M.Hung, E.J.Tokarsky, L.Lagpacan, L.Zhang, Z.Suo, E.B.Lansdon. Elucidating Molecular Interactions of L-Nucleotides with Hiv-1 Reverse Transcriptase and Mechanism of M184V-Caused Drug Resistance Commun Biol V. 2 2019.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-019-0706-X