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Magnesium in PDB 6ujx: Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp

Enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp

All present enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; 3.4.23.16;

Protein crystallography data

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp, PDB code: 6ujx was solved by E.B.Lansdon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.60 / 2.70
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 169.804, 167.685, 103.309, 90.00, 90.00, 90.00
R / Rfree (%) 19.7 / 24.4

Other elements in 6ujx:

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp also contains other interesting chemical elements:

Fluorine (F) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp (pdb code 6ujx). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp, PDB code: 6ujx:

Magnesium binding site 1 out of 1 in 6ujx

Go back to Magnesium Binding Sites List in 6ujx
Magnesium binding site 1 out of 1 in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (-)-Ftc-Tp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg603

b:41.0
occ:1.00
 OAG A:1RY604 1.6 45.9 0.6
O A:VAL111 2.0 36.9 1.0
OD2 A:ASP110 2.1 43.8 1.0
OAH A:1RY604 2.1 40.8 0.6
OD2 A:ASP185 2.4 45.6 1.0
OAE A:1RY604 2.5 41.6 0.6
OAQ A:1RY604 2.5 48.9 0.5
OAD A:1RY604 2.5 41.8 0.5
PAZ A:1RY604 3.1 48.8 0.6
OAI A:1RY604 3.2 47.1 0.5
C A:VAL111 3.2 34.5 1.0
PBA A:1RY604 3.3 46.2 0.6
PBB A:1RY604 3.3 45.8 0.6
CG A:ASP110 3.3 42.6 1.0
OAF A:1RY604 3.4 45.8 0.5
PBB A:1RY604 3.4 48.6 0.5
CG A:ASP185 3.5 34.5 1.0
PAZ A:1RY604 3.6 48.5 0.5
OAR A:1RY604 3.6 44.9 0.6
OAQ A:1RY604 3.6 44.1 0.6
PBA A:1RY604 3.8 46.4 0.5
OAR A:1RY604 3.9 44.2 0.5
OAC A:1RY604 3.9 46.8 0.6
N A:VAL111 3.9 34.7 1.0
OAF A:1RY604 4.1 49.7 0.6
OAO A:1RY604 4.1 40.0 0.6
N A:GLY112 4.1 32.4 1.0
CA A:VAL111 4.1 30.2 1.0
CA A:GLY112 4.1 29.2 1.0
OD1 A:ASP110 4.2 54.1 1.0
CB A:ASP110 4.2 34.0 1.0
CAL A:1RY604 4.3 39.1 0.5
CAL A:1RY604 4.3 39.1 0.6
OD1 A:ASP185 4.3 32.2 1.0
N A:ASP113 4.3 39.0 1.0
NZ A:LYS220 4.4 45.1 1.0
OAC A:1RY604 4.4 45.3 0.5
CB A:ASP185 4.4 29.9 1.0
C A:GLY112 4.5 36.1 1.0
OAO A:1RY604 4.5 37.3 0.5
C A:ASP110 4.5 31.9 1.0
N A:ALA114 4.6 35.0 1.0
OAG A:1RY604 4.6 49.6 0.5
OAD A:1RY604 4.6 40.1 0.6
CB A:ALA114 4.7 29.7 1.0
CB A:VAL111 4.7 31.4 1.0
OAE A:1RY604 4.7 47.0 0.5
OAI A:1RY604 4.8 48.2 0.6
CA A:ASP110 4.8 30.0 1.0

Reference:

M.Hung, E.J.Tokarsky, L.Lagpacan, L.Zhang, Z.Suo, E.B.Lansdon. Elucidating Molecular Interactions of L-Nucleotides with Hiv-1 Reverse Transcriptase and Mechanism of M184V-Caused Drug Resistance Commun Biol V. 2 2019.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-019-0706-X
Page generated: Tue Oct 1 21:05:40 2024

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