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Magnesium in PDB 6ujz: Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

Enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

All present enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp:
2.7.7.49; 2.7.7.7; 3.1.26.13;

Protein crystallography data

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp, PDB code: 6ujz was solved by E.B.Lansdon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.34 / 2.56
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 168.277, 168.829, 102.548, 90.00, 90.00, 90.00
R / Rfree (%) 18.5 / 23.6

Other elements in 6ujz:

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp also contains other interesting chemical elements:

Fluorine (F) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp (pdb code 6ujz). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp, PDB code: 6ujz:

Magnesium binding site 1 out of 1 in 6ujz

Go back to Magnesium Binding Sites List in 6ujz
Magnesium binding site 1 out of 1 in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg603

b:41.6
occ:1.00
 OD2 A:ASP110 1.9 53.4 1.0
OAD A:N8G604 2.0 48.2 1.0
OAC A:N8G604 2.1 58.5 1.0
O A:VAL111 2.1 48.8 1.0
OAI A:N8G604 2.2 51.7 1.0
OD2 A:ASP185 2.3 53.8 1.0
CG A:ASP110 2.9 53.6 1.0
PBB A:N8G604 3.2 52.0 1.0
OD1 A:ASP110 3.3 63.7 1.0
PAZ A:N8G604 3.3 51.4 1.0
C A:VAL111 3.3 50.2 1.0
CG A:ASP185 3.5 49.2 1.0
PBA A:N8G604 3.5 48.1 1.0
OAQ A:N8G604 3.6 49.6 1.0
OAR A:N8G604 3.7 49.9 1.0
OD1 A:ASP185 4.0 46.2 1.0
NZ A:LYS220 4.0 61.1 1.0
N A:VAL111 4.1 44.7 1.0
CAL A:N8G604 4.2 46.5 1.0
CB A:ASP110 4.2 44.8 1.0
N A:GLY112 4.3 51.1 1.0
CA A:VAL111 4.3 47.6 1.0
OAO A:N8G604 4.3 48.3 1.0
OAF A:N8G604 4.3 62.3 1.0
CA A:GLY112 4.3 47.4 1.0
C A:ASP110 4.4 48.0 1.0
N A:ASP113 4.4 53.5 1.0
OAH A:N8G604 4.5 49.5 1.0
OAG A:N8G604 4.6 61.7 1.0
OAE A:N8G604 4.7 56.9 1.0
CB A:ASP185 4.7 48.3 1.0
C A:GLY112 4.7 50.8 1.0
N A:ALA114 4.7 51.3 1.0
CB A:ALA114 4.7 51.3 1.0
CA A:ASP110 4.8 49.5 1.0
O A:ASP110 4.9 50.4 1.0
CB A:VAL111 4.9 45.0 1.0
CE A:LYS220 4.9 58.8 1.0

Reference:

M.Hung, E.J.Tokarsky, L.Lagpacan, L.Zhang, Z.Suo, E.B.Lansdon. Elucidating Molecular Interactions of L-Nucleotides with Hiv-1 Reverse Transcriptase and Mechanism of M184V-Caused Drug Resistance Commun Biol V. 2 2019.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-019-0706-X
Page generated: Tue Oct 1 21:06:08 2024

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