Magnesium in PDB 6ujz: Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

Enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

All present enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp:
2.7.7.49; 2.7.7.7; 3.1.26.13;

Protein crystallography data

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp, PDB code: 6ujz was solved by E.B.Lansdon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	47.34 / 2.56
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	168.277, 168.829, 102.548, 90.00, 90.00, 90.00
*R / R_free (%)*	18.5 / 23.6

Other elements in 6ujz:

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp also contains other interesting chemical elements:

Fluorine

(F)

1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp (pdb code 6ujz). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp, PDB code: 6ujz:

Magnesium binding site 1 out of 1 in 6ujz

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Magnesium Binding Sites List in 6ujz

Magnesium binding site 1 out of 1 in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg603 b:41.6 occ:1.00	OD2	A:ASP110	1.9	53.4	1.0
	OAD	A:N8G604	2.0	48.2	1.0
	OAC	A:N8G604	2.1	58.5	1.0
	O	A:VAL111	2.1	48.8	1.0
	OAI	A:N8G604	2.2	51.7	1.0
	OD2	A:ASP185	2.3	53.8	1.0
	CG	A:ASP110	2.9	53.6	1.0
	PBB	A:N8G604	3.2	52.0	1.0
	OD1	A:ASP110	3.3	63.7	1.0
	PAZ	A:N8G604	3.3	51.4	1.0
	C	A:VAL111	3.3	50.2	1.0
	CG	A:ASP185	3.5	49.2	1.0
	PBA	A:N8G604	3.5	48.1	1.0
	OAQ	A:N8G604	3.6	49.6	1.0
	OAR	A:N8G604	3.7	49.9	1.0
	OD1	A:ASP185	4.0	46.2	1.0
	NZ	A:LYS220	4.0	61.1	1.0
	N	A:VAL111	4.1	44.7	1.0
	CAL	A:N8G604	4.2	46.5	1.0
	CB	A:ASP110	4.2	44.8	1.0
	N	A:GLY112	4.3	51.1	1.0
	CA	A:VAL111	4.3	47.6	1.0
	OAO	A:N8G604	4.3	48.3	1.0
	OAF	A:N8G604	4.3	62.3	1.0
	CA	A:GLY112	4.3	47.4	1.0
	C	A:ASP110	4.4	48.0	1.0
	N	A:ASP113	4.4	53.5	1.0
	OAH	A:N8G604	4.5	49.5	1.0
	OAG	A:N8G604	4.6	61.7	1.0
	OAE	A:N8G604	4.7	56.9	1.0
	CB	A:ASP185	4.7	48.3	1.0
	C	A:GLY112	4.7	50.8	1.0
	N	A:ALA114	4.7	51.3	1.0
	CB	A:ALA114	4.7	51.3	1.0
	CA	A:ASP110	4.8	49.5	1.0
	O	A:ASP110	4.9	50.4	1.0
	CB	A:VAL111	4.9	45.0	1.0
	CE	A:LYS220	4.9	58.8	1.0

Reference:

M.Hung, E.J.Tokarsky, L.Lagpacan, L.Zhang, Z.Suo, E.B.Lansdon. Elucidating Molecular Interactions of L-Nucleotides with Hiv-1 Reverse Transcriptase and Mechanism of M184V-Caused Drug Resistance Commun Biol V. 2 2019.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-019-0706-X

Page generated: Tue Oct 1 21:06:08 2024

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