Magnesium in PDB 6uk0: Hiv-1 M184V Reverse Transcriptase-Dna Complex

All present enzymatic activity of Hiv-1 M184V Reverse Transcriptase-Dna Complex:
2.7.7.49; 2.7.7.7; 3.1.26.13;

The structure of Hiv-1 M184V Reverse Transcriptase-Dna Complex, PDB code: 6uk0 was solved by E.B.Lansdon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.68 / 2.76
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	167.982, 169.682, 97.368, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 26

The binding sites of Magnesium atom in the Hiv-1 M184V Reverse Transcriptase-Dna Complex (pdb code 6uk0). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 M184V Reverse Transcriptase-Dna Complex, PDB code: 6uk0:

Magnesium binding site 1 out of 1 in the Hiv-1 M184V Reverse Transcriptase-Dna Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 M184V Reverse Transcriptase-Dna Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg601 b:50.2 occ:1.00 OD2 A:ASP498 2.6 41.1 1.0 OD2 A:ASP443 2.7 43.7 1.0 OD1 A:ASP443 3.0 47.0 1.0 OD2 A:ASP549 3.0 56.5 1.0 CG A:ASP443 3.2 42.1 1.0 CG A:ASP498 3.6 46.7 1.0 CG A:ASP549 3.8 57.2 1.0 OD1 A:ASP498 4.0 47.8 1.0 OD1 A:ASP549 4.3 58.8 1.0 O A:GLY444 4.3 35.1 1.0 CE1 A:HIS539 4.4 51.3 1.0 CB A:ALA538 4.4 36.6 1.0 NE2 A:HIS539 4.7 51.5 1.0 CB A:ASP443 4.7 44.0 1.0 CB A:ASP549 4.8 50.5 1.0 CB A:ASP498 4.9 39.2 1.0 OE2 A:GLU478 4.9 63.4 1.0

M.Hung, E.J.Tokarsky, L.Lagpacan, L.Zhang, Z.Suo, E.B.Lansdon. Elucidating Molecular Interactions of L-Nucleotides with Hiv-1 Reverse Transcriptase and Mechanism of M184V-Caused Drug Resistance Commun Biol V. 2 2019.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-019-0706-X