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Magnesium in PDB 6vpg: TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp

Enzymatic activity of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp

All present enzymatic activity of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp:
2.7.11.1;

Protein crystallography data

The structure of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp, PDB code: 6vpg was solved by D.C.Lim, M.B.Yaffe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.08 / 2.64
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 83.562, 83.562, 114.516, 90.00, 90.00, 90.00
R / Rfree (%) 19.9 / 24.5

Other elements in 6vpg:

The structure of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp (pdb code 6vpg). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp, PDB code: 6vpg:

Magnesium binding site 1 out of 1 in 6vpg

Go back to Magnesium Binding Sites List in 6vpg
Magnesium binding site 1 out of 1 in the TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg405

b:0.1
occ:1.00
 O2B A:ANP401 2.2 0.5 1.0
OD1 A:ASP274 2.4 0.7 1.0
CG A:ASP274 3.2 0.3 1.0
C3 A:GOL402 3.2 95.6 1.0
O3 A:GOL402 3.3 90.8 1.0
OD2 A:ASP274 3.4 0.0 1.0
NZ A:LYS162 3.5 93.9 1.0
PB A:ANP401 3.6 0.2 1.0
O1B A:ANP401 3.9 0.1 1.0
O2A A:ANP401 3.9 0.2 1.0
CA A:GLY276 4.1 69.8 1.0
O A:HOH503 4.1 70.2 1.0
OE1 A:GLU181 4.4 71.8 1.0
N A:GLY276 4.4 67.4 1.0
N3B A:ANP401 4.5 0.0 1.0
OE2 A:GLU181 4.5 70.1 1.0
CB A:ASP274 4.6 85.2 1.0
C2 A:GOL402 4.6 0.9 1.0
CE A:LYS162 4.6 93.0 1.0
O3A A:ANP401 4.7 0.9 1.0
CD A:GLU181 4.7 68.6 1.0
PA A:ANP401 4.8 0.8 1.0
CD A:LYS143 4.8 0.1 1.0
O A:HOH507 4.8 84.9 1.0
C1 A:GOL402 5.0 0.3 1.0
O1A A:ANP401 5.0 0.2 1.0
CA A:ASP274 5.0 74.1 1.0

Reference:

D.C.Lim, V.Joukov, T.J.Rettenmaier, A.Kumagai, W.G.Dunphy, J.A.Wells, M.B.Yaffe. Redox Priming Promotes Aurora A Activation During Mitosis. Sci.Signal. V. 13 2020.
ISSN: ESSN 1937-9145
PubMed: 32694171
DOI: 10.1126/SCISIGNAL.ABB6707
Page generated: Tue Oct 1 22:11:26 2024

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