Magnesium in PDB 6xha: Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf

Enzymatic activity of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf

All present enzymatic activity of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf:
2.7.11.1; 3.6.5.2;

Protein crystallography data

The structure of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf, PDB code: 6xha was solved by T.H.Tran, A.H.Chan, S.Dharmaiah, D.K.Simanshu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.30 / 2.87
Space group P 6 2 2
Cell size a, b, c (Å), α, β, γ (°) 132.1, 132.1, 90.17, 90, 90, 120
R / Rfree (%) 21.7 / 26.9

Other elements in 6xha:

The structure of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf also contains other interesting chemical elements:

Arsenic (As) 1 atom
Zinc (Zn) 2 atoms
Chlorine (Cl) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf (pdb code 6xha). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf, PDB code: 6xha:

Magnesium binding site 1 out of 1 in 6xha

Go back to Magnesium Binding Sites List in 6xha
Magnesium binding site 1 out of 1 in the Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg203

b:81.6
occ:1.00
 OG A:SER17 2.0 79.7 1.0
O A:HOH302 2.1 67.8 1.0
OG1 A:THR35 2.1 93.0 1.0
O A:HOH301 2.1 89.8 1.0
O1B A:GNP201 2.1 98.3 0.9
O2G A:GNP201 2.1 91.0 0.9
PG A:GNP201 2.9 92.5 0.9
PB A:GNP201 3.0 92.8 0.9
CB A:THR35 3.0 80.2 1.0
N3B A:GNP201 3.1 90.7 0.9
CB A:SER17 3.3 81.2 1.0
O1G A:GNP201 3.4 79.0 0.9
N A:THR35 3.5 86.0 1.0
O1A A:GNP201 3.6 86.9 0.9
N A:SER17 3.8 87.9 1.0
OD2 A:ASP57 3.9 109.7 1.0
CA A:THR35 3.9 71.5 1.0
O2B A:GNP201 4.0 101.5 0.9
O3G A:GNP201 4.1 96.2 0.9
CA A:SER17 4.1 79.8 1.0
CG2 A:THR35 4.1 96.7 1.0
O3A A:GNP201 4.1 90.0 0.9
OD1 A:ASP57 4.2 94.8 1.0
PA A:GNP201 4.3 88.5 0.9
O A:ASP33 4.3 122.0 1.0
C A:PRO34 4.4 96.2 1.0
CG A:ASP57 4.4 102.2 1.0
O A:THR58 4.6 104.0 1.0
CA A:PRO34 4.7 107.8 1.0
CB A:LYS16 4.7 83.4 1.0
CE A:LYS16 4.7 87.5 1.0
C A:LYS16 4.8 89.2 1.0
NZ A:LYS16 4.8 100.1 1.0
O2A A:GNP201 4.9 88.4 0.9

Reference:

T.H.Tran, A.H.Chan, S.Dharmaiah, D.K.Simanshu. Crystal Structure of Wild-Type Kras (Gmppnp-Bound) in Complex with Ras-Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf (Crystal Form I) Nat Commun 2020.
ISSN: ESSN 2041-1723
Page generated: Mon Jan 25 15:17:55 2021

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