Magnesium in PDB 7acd: Crystal Structure of the Human METTL3-METTL14 Complex with Compound T30 (UZH1A)

All present enzymatic activity of Crystal Structure of the Human METTL3-METTL14 Complex with Compound T30 (UZH1A):
2.1.1.348;

The structure of Crystal Structure of the Human METTL3-METTL14 Complex with Compound T30 (UZH1A), PDB code: 7acd was solved by R.K.Bedi, D.Huang, A.Caflisch, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.48 / 2.50
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	63.800, 63.800, 224.920, 90.00, 90.00, 120.00
R / Rfree (%)	18.8 / 22.6

The binding sites of Magnesium atom in the Crystal Structure of the Human METTL3-METTL14 Complex with Compound T30 (UZH1A) (pdb code 7acd). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of the Human METTL3-METTL14 Complex with Compound T30 (UZH1A), PDB code: 7acd:

Magnesium binding site 1 out of 1 in the Crystal Structure of the Human METTL3-METTL14 Complex with Compound T30 (UZH1A)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Human METTL3-METTL14 Complex with Compound T30 (UZH1A) within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg402 b:43.7 occ:1.00 NE2 B:HIS336 2.2 59.2 1.0 CE1 B:HIS336 2.5 52.7 1.0 OD2 B:ASP157 3.0 83.3 1.0 CD2 B:HIS332 3.0 60.6 1.0 OD1 B:ASP157 3.1 67.4 1.0 CG B:HIS332 3.2 60.9 1.0 CB B:HIS332 3.2 46.3 1.0 CG B:ASP157 3.4 74.8 1.0 CD2 B:HIS336 3.5 49.6 1.0 ND1 B:HIS336 3.8 53.9 1.0 NE2 B:HIS332 4.0 64.0 1.0 CA B:HIS332 4.1 38.6 1.0 ND1 B:HIS332 4.2 62.9 1.0 CG B:HIS336 4.3 50.9 1.0 CE1 B:HIS332 4.6 58.4 1.0 C B:HIS332 4.7 36.8 1.0 O B:HIS332 4.8 39.2 1.0 CB B:ASP157 4.9 63.0 1.0

E.V.Moroz-Omori, D.Huang, R.K.Bedi, S.J.Cheriyamkunnel, E.Bochenkova, A.Dolbois, M.D.Rzeczkowski, L.Wiedmer, A.Caflisch. METTL3 Inhibitors For Epitranscriptomic Modulation of Cellular Processes Biorxiv 2020.
DOI: 10.1101/2020.09.25.311803