Magnesium in PDB 7aqb: Crystal Structure of Human Mitogen Activated Protein Kinase 6 (MAPK6)

All present enzymatic activity of Crystal Structure of Human Mitogen Activated Protein Kinase 6 (MAPK6):
2.7.11.24;

The structure of Crystal Structure of Human Mitogen Activated Protein Kinase 6 (MAPK6), PDB code: 7aqb was solved by P.Filippakopoulos, M.Schroeder, A.Chaikuad, S.Knapp, Structural Genomicsconsortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.88 / 2.25
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	83.317, 83.317, 181.066, 90.00, 90.00, 90.00
R / Rfree (%)	22.2 / 25.8

The binding sites of Magnesium atom in the Crystal Structure of Human Mitogen Activated Protein Kinase 6 (MAPK6) (pdb code 7aqb). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Mitogen Activated Protein Kinase 6 (MAPK6), PDB code: 7aqb:

Magnesium binding site 1 out of 1 in the Crystal Structure of Human Mitogen Activated Protein Kinase 6 (MAPK6)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Mitogen Activated Protein Kinase 6 (MAPK6) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg401 b:68.7 occ:1.00 OD1 A:ASN157 2.2 45.0 1.0 OD2 A:ASP171 2.3 69.5 1.0 CG A:ASN157 3.4 40.7 1.0 CG A:ASP171 3.5 64.4 1.0 O A:ALA156 3.9 44.6 1.0 CB A:ASP171 4.0 56.0 1.0 ND2 A:ASN157 4.1 41.7 1.0 C A:ALA156 4.3 39.3 1.0 OD1 A:ASP171 4.5 68.0 1.0 CA A:ASN157 4.6 36.8 1.0 CB A:ALA156 4.6 37.4 1.0 CB A:ASN157 4.6 38.7 1.0 N A:ASN157 4.6 37.9 1.0 CZ A:PHE159 4.9 43.3 1.0

M.Schroder, P.Filippakopoulos, M.P.Schwalm, C.A.Ferrer, D.H.Drewry, S.Knapp, A.Chaikuad. Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity For the Atypical Mapk Kinase ERK3. Int J Mol Sci V. 21 2020.
ISSN: ESSN 1422-0067
PubMed: 33114754
DOI: 10.3390/IJMS21217953