Atomistry » Magnesium » PDB 7ba7-7bog » 7bbj
Atomistry »
  Magnesium »
    PDB 7ba7-7bog »
      7bbj »

Magnesium in PDB 7bbj: CD73 in Complex with the Humanized Antagonistic Antibody MAB19

Enzymatic activity of CD73 in Complex with the Humanized Antagonistic Antibody MAB19

All present enzymatic activity of CD73 in Complex with the Humanized Antagonistic Antibody MAB19:
3.1.3.5;

Protein crystallography data

The structure of CD73 in Complex with the Humanized Antagonistic Antibody MAB19, PDB code: 7bbj was solved by J.Boettcher, F.Han, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.83 / 2.72
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 133.35, 67.74, 150.05, 90, 100.13, 90
R / Rfree (%) 20.8 / 23.4

Other elements in 7bbj:

The structure of CD73 in Complex with the Humanized Antagonistic Antibody MAB19 also contains other interesting chemical elements:

Zinc (Zn) 4 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the CD73 in Complex with the Humanized Antagonistic Antibody MAB19 (pdb code 7bbj). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the CD73 in Complex with the Humanized Antagonistic Antibody MAB19, PDB code: 7bbj:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 7bbj

Go back to Magnesium Binding Sites List in 7bbj
Magnesium binding site 1 out of 2 in the CD73 in Complex with the Humanized Antagonistic Antibody MAB19


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of CD73 in Complex with the Humanized Antagonistic Antibody MAB19 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg803

b:59.8
occ:1.00
O A:GLY298 2.6 62.6 1.0
OD1 A:ASP237 2.6 61.8 1.0
O A:ASN213 2.7 56.7 1.0
OD2 A:ASP237 3.0 66.4 1.0
CG A:ASP237 3.2 60.3 1.0
C A:GLY298 3.5 63.2 1.0
C A:ASN213 3.9 56.3 1.0
N A:ASN299 4.3 58.5 1.0
CA A:GLY298 4.3 61.0 1.0
O A:ARG297 4.5 65.5 1.0
OD1 A:ASN299 4.5 70.8 1.0
CA A:ASN299 4.5 57.8 1.0
O A:GLY235 4.5 53.8 1.0
CA A:ASN213 4.6 53.8 1.0
CB A:ASP237 4.7 47.8 1.0
N A:LYS214 4.8 50.5 1.0
CB A:ASN213 4.9 53.5 1.0
CA A:LYS214 5.0 48.9 1.0

Magnesium binding site 2 out of 2 in 7bbj

Go back to Magnesium Binding Sites List in 7bbj
Magnesium binding site 2 out of 2 in the CD73 in Complex with the Humanized Antagonistic Antibody MAB19


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of CD73 in Complex with the Humanized Antagonistic Antibody MAB19 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg803

b:53.1
occ:1.00
O B:GLY298 2.3 63.2 1.0
O B:ASN213 2.4 51.8 1.0
OD1 B:ASP237 2.5 57.3 1.0
OD2 B:ASP237 2.6 62.9 1.0
CG B:ASP237 2.9 56.0 1.0
C B:GLY298 3.3 63.7 1.0
C B:ASN213 3.6 51.8 1.0
CA B:GLY298 4.1 60.8 1.0
N B:ASN299 4.2 59.4 1.0
CB B:ASP237 4.4 42.0 1.0
CA B:ASN299 4.5 58.5 1.0
CA B:ASN213 4.5 50.3 1.0
N B:LYS214 4.5 46.1 1.0
O B:ARG297 4.5 65.0 1.0
O B:GLY235 4.6 48.4 1.0
CA B:LYS214 4.6 44.9 1.0
OD1 B:ASN299 4.7 75.4 1.0
CB B:ASN213 4.8 49.8 1.0

Reference:

M.Wurm, O.Schaaf, K.Reutner, R.Ganesan, S.Mostbock, C.Pelster, J.Bottcher, C.Taubert, I.Alt, G.Serna, A.Auguste, K.B.Stadermann, D.Delic, F.Han, J.Capdevila, P.G.Nuciforo, R.Kroe-Barrett, P.J.Adam, A.B.Vogt, I.Hofmann. A Novel Antagonistic CD73 Antibody For Inhibition of the Immunosuppressive Adenosine Pathway Mol.Cancer Ther. 2021.
ISSN: ESSN 1538-8514
DOI: 10.1158/1535-7163.MCT-21-0107
Page generated: Thu Mar 31 04:05:19 2022

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy