Magnesium in PDB 7e7q: Cryo-Em Structure of Human ABCA4 in Atp-Bound State

All present enzymatic activity of Cryo-Em Structure of Human ABCA4 in Atp-Bound State:
7.6.2.1;

The binding sites of Magnesium atom in the Cryo-Em Structure of Human ABCA4 in Atp-Bound State (pdb code 7e7q). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cryo-Em Structure of Human ABCA4 in Atp-Bound State, PDB code: 7e7q:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cryo-Em Structure of Human ABCA4 in Atp-Bound State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of Human ABCA4 in Atp-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg2310 b:27.6 occ:1.00 O3G A:ATP2308 1.9 22.8 1.0 OG1 A:THR970 2.0 28.2 1.0 OE1 A:GLN1010 2.0 28.2 1.0 O2B A:ATP2308 2.3 22.8 1.0 CD A:GLN1010 3.0 28.2 1.0 PG A:ATP2308 3.2 22.8 1.0 CB A:THR970 3.2 28.2 1.0 NE2 A:GLN1010 3.4 28.2 1.0 PB A:ATP2308 3.4 22.8 1.0 O3B A:ATP2308 3.7 22.8 1.0 O1G A:ATP2308 3.7 22.8 1.0 CG2 A:THR970 4.0 28.2 1.0 CG A:GLN1010 4.3 28.2 1.0 N A:THR970 4.3 28.2 1.0 CA A:THR970 4.3 28.2 1.0 O1A A:ATP2308 4.3 22.8 1.0 O1B A:ATP2308 4.3 22.8 1.0 O A:SER2072 4.3 29.6 1.0 OD2 A:ASP1086 4.4 23.8 1.0 O2G A:ATP2308 4.4 22.8 1.0 CB A:GLN1010 4.5 28.2 1.0 O3A A:ATP2308 4.6 22.8 1.0 PA A:ATP2308 4.9 22.8 1.0 CG A:GLN1087 5.0 24.7 1.0

Magnesium binding site 2 out of 2 in the Cryo-Em Structure of Human ABCA4 in Atp-Bound State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of Human ABCA4 in Atp-Bound State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg2311 b:38.6 occ:1.00 O2G A:ATP2309 1.9 33.1 1.0 OE1 A:GLN2019 2.0 30.7 1.0 OG1 A:THR1979 2.1 26.3 1.0 O2B A:ATP2309 2.1 33.1 1.0 CD A:GLN2019 3.1 30.7 1.0 PG A:ATP2309 3.2 33.1 1.0 CB A:THR1979 3.3 26.3 1.0 PB A:ATP2309 3.3 33.1 1.0 O3B A:ATP2309 3.5 33.1 1.0 NE2 A:GLN2019 3.8 30.7 1.0 O3G A:ATP2309 4.0 33.1 1.0 CG2 A:THR1979 4.1 26.3 1.0 O1A A:ATP2309 4.1 33.1 1.0 N A:THR1979 4.2 26.3 1.0 CG A:GLN2019 4.3 30.7 1.0 O1G A:ATP2309 4.3 33.1 1.0 O1B A:ATP2309 4.3 33.1 1.0 CA A:THR1979 4.3 26.3 1.0 O3A A:ATP2309 4.4 33.1 1.0 O A:SER1063 4.6 31.8 1.0 PA A:ATP2309 4.7 33.1 1.0 OD2 A:ASP2095 4.7 33.2 1.0 CB A:GLN2019 4.8 30.7 1.0 NE2 A:GLN2096 4.9 31.6 1.0

T.Xie, Z.K.Zhang, Q.Fang, B.W.Du, X.Gong. Structural Basis of Substrate Recognition and Translocation By Human ABCA4 Nat Commun 2021.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-021-24194-6