Magnesium in PDB 7egq: Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading

Enzymatic activity of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading

All present enzymatic activity of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading:
2.7.7.48; 3.6.4.12; 3.6.4.13;

Other elements in 7egq:

The structure of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading also contains other interesting chemical elements:

Zinc (Zn) 26 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading (pdb code 7egq). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading, PDB code: 7egq:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in 7egq

Go back to Magnesium Binding Sites List in 7egq
Magnesium binding site 1 out of 3 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Mg603

b:69.8
occ:1.00
OD2 K:ASP273 2.9 79.7 1.0
OD2 K:ASP90 3.0 79.7 1.0
CG K:ASP90 3.9 79.7 1.0
CG K:ASP273 3.9 79.7 1.0
OD1 K:ASP90 4.0 79.7 1.0
CG K:GLU92 4.0 79.7 1.0
O K:VAL91 4.2 79.7 1.0
OE2 K:GLU92 4.2 79.7 1.0
MG K:MG604 4.5 84.9 1.0
O K:VAL269 4.6 79.7 1.0
CD K:GLU92 4.6 79.7 1.0
CB K:ASP273 4.7 79.7 1.0
OD1 K:ASP273 4.7 79.7 1.0

Magnesium binding site 2 out of 3 in 7egq

Go back to Magnesium Binding Sites List in 7egq
Magnesium binding site 2 out of 3 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Mg604

b:84.9
occ:1.00
O K:VAL269 2.5 79.7 1.0
N K:VAL269 3.3 79.7 1.0
C K:VAL269 3.5 79.7 1.0
SG K:CYS272 3.6 79.7 1.0
CA K:HIS268 3.7 89.7 1.0
C K:HIS268 3.8 89.7 1.0
OD1 K:ASN266 3.8 79.7 1.0
CA K:VAL269 4.0 79.7 1.0
OD1 K:ASP273 4.3 79.7 1.0
CB K:HIS268 4.3 89.7 1.0
CG K:HIS268 4.4 89.7 1.0
OE2 K:GLU92 4.4 79.7 1.0
O K:ALA267 4.5 84.9 1.0
MG K:MG603 4.5 69.8 1.0
CD2 K:HIS268 4.6 89.7 1.0
OD2 K:ASP273 4.6 79.7 1.0
CG K:ASP273 4.7 79.7 1.0
ND2 K:ASN266 4.7 79.7 1.0
O K:HIS268 4.7 89.7 1.0
CG K:ASN266 4.7 79.7 1.0
N K:ALA270 4.7 79.7 1.0
NE2 K:HIS148 4.7 94.6 1.0
ND1 K:HIS268 4.8 89.7 1.0
N K:HIS268 4.9 89.7 1.0
CE1 K:HIS148 5.0 94.6 1.0

Magnesium binding site 3 out of 3 in 7egq

Go back to Magnesium Binding Sites List in 7egq
Magnesium binding site 3 out of 3 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
X:Mg603

b:75.4
occ:1.00
OE2 X:GLU92 2.3 79.7 1.0
CD X:GLU92 2.8 79.7 1.0
OD1 X:ASP90 2.8 79.7 1.0
OD2 X:ASP273 3.3 79.7 1.0
OD2 X:ASP90 3.5 79.7 1.0
CG X:GLU92 3.5 79.7 1.0
OE1 X:GLU92 3.5 79.7 1.0
CG X:ASP90 3.5 79.7 1.0
O X:VAL91 3.7 79.7 1.0
CG X:ASP273 4.4 79.7 1.0
C X:VAL91 4.5 79.7 1.0
CB X:GLU92 4.6 79.7 1.0
CA X:GLU92 4.9 79.7 1.0
CB X:ASP273 4.9 79.7 1.0
N X:GLU92 4.9 79.7 1.0
CB X:ASP90 5.0 79.7 1.0

Reference:

L.Yan, Y.Yang, M.Li, Y.Zhang, L.Zheng, J.Ge, Y.C.Huang, Z.Liu, T.Wang, S.Gao, R.Zhang, Y.Y.Huang, L.W.Guddat, Y.Gao, Z.Rao, Z.Lou. Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars-Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading. Cell V. 184 3474 2021.
ISSN: ISSN 1097-4172
PubMed: 34143953
DOI: 10.1016/J.CELL.2021.05.033
Page generated: Sat Aug 21 16:24:16 2021

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