Magnesium in PDB 7kl1: Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp

All present enzymatic activity of Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp:
2.7.11.17;

The structure of Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp, PDB code: 7kl1 was solved by C.Ozden, M.M.Stratton, S.C.Garman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.50 / 2.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	72.893, 92.133, 91.338, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 26.5

The binding sites of Magnesium atom in the Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp (pdb code 7kl1). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp, PDB code: 7kl1:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg307 b:42.9 occ:1.00 O2B A:ATP306 2.0 54.1 1.0 OD2 A:ASP156 2.3 30.2 1.0 OD1 A:ASN140 2.5 20.6 1.0 O5' A:ATP306 2.8 47.3 1.0 PB A:ATP306 3.1 70.4 1.0 O3A A:ATP306 3.2 44.3 1.0 PA A:ATP306 3.3 42.0 1.0 O2A A:ATP306 3.3 36.5 1.0 CG A:ASP156 3.5 34.6 1.0 CG A:ASN140 3.6 21.2 1.0 O A:GLU139 3.7 26.5 1.0 O1G A:ATP306 3.9 67.8 1.0 O3B A:ATP306 3.9 54.4 1.0 C3' A:ATP306 4.1 36.6 1.0 C5' A:ATP306 4.1 38.2 1.0 ND2 A:ASN140 4.2 17.9 1.0 C A:GLU139 4.3 21.2 1.0 CB A:ASP156 4.3 26.1 1.0 O1B A:ATP306 4.4 55.7 1.0 PG A:ATP306 4.5 65.0 1.0 OD1 A:ASP156 4.5 33.5 1.0 C2' A:ATP306 4.5 35.9 1.0 CB A:GLU139 4.5 19.9 1.0 CA A:ASN140 4.6 22.7 1.0 N A:ASN140 4.6 23.8 1.0 OE1 A:GLU96 4.7 43.1 1.0 C4' A:ATP306 4.7 39.4 1.0 CB A:ASN140 4.7 21.8 1.0 O1A A:ATP306 4.7 59.0 1.0 O2G A:ATP306 4.8 76.9 1.0 CE A:LYS137 4.8 19.7 1.0

Magnesium binding site 2 out of 2 in the Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg308 b:27.6 occ:1.00 OD2 B:ASP156 1.9 20.4 1.0 O B:HOH420 2.1 17.2 1.0 OD1 B:ASN140 2.1 17.9 1.0 O2B B:ATP307 2.1 25.1 1.0 O2A B:ATP307 2.1 24.1 1.0 O B:HOH407 2.2 16.4 1.0 CG B:ASP156 3.0 22.8 1.0 CG B:ASN140 3.2 18.8 1.0 PB B:ATP307 3.3 31.1 1.0 PA B:ATP307 3.3 26.4 1.0 O3A B:ATP307 3.4 24.2 1.0 CB B:ASP156 3.5 21.1 1.0 ND2 B:ASN140 3.8 18.7 1.0 O B:GLU139 4.0 20.7 1.0 O1G B:ATP307 4.0 35.0 1.0 OD1 B:ASP156 4.1 22.5 1.0 O3B B:ATP307 4.2 28.5 1.0 O5' B:ATP307 4.2 26.2 1.0 C5' B:ATP307 4.2 26.8 1.0 C3' B:ATP307 4.3 25.3 1.0 O1B B:ATP307 4.4 27.0 1.0 O1A B:ATP307 4.4 29.3 1.0 CB B:ASN140 4.5 18.4 1.0 C B:GLU139 4.5 22.1 1.0 C2' B:ATP307 4.5 25.0 1.0 CA B:ASN140 4.6 18.3 1.0 OE1 B:GLU96 4.6 24.9 1.0 PG B:ATP307 4.6 33.3 1.0 O3G B:ATP307 4.8 30.2 1.0 N B:ASN140 4.8 19.6 1.0 CB B:GLU139 4.8 20.1 1.0 C4' B:ATP307 4.8 28.1 1.0

C.Ozden, M.M.Stratton, S.C.Garman. Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B(S1303D) in Complex with Atp To Be Published.