Magnesium in PDB 7kro: Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc

All present enzymatic activity of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc:
2.7.7.48; 3.6.4.12; 3.6.4.13;

The structure of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc also contains other interesting chemical elements:

Aluminium	(Al)	2 atoms
Zinc	(Zn)	8 atoms
Fluorine	(F)	6 atoms

The binding sites of Magnesium atom in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc (pdb code 7kro). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc, PDB code: 7kro:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1003 b:41.3 occ:1.00 O2A A:ADP1004 1.6 52.8 1.0 O1B A:ADP1004 1.9 52.8 1.0 OD1 A:ASN209 2.0 34.7 1.0 OD2 A:ASP218 2.1 37.4 1.0 OD1 A:ASP208 2.1 39.1 1.0 PA A:ADP1004 2.8 52.8 1.0 CG A:ASN209 3.1 34.7 1.0 CG A:ASP218 3.2 37.4 1.0 O1A A:ADP1004 3.3 52.8 1.0 CG A:ASP208 3.3 39.1 1.0 PB A:ADP1004 3.4 52.8 1.0 O3A A:ADP1004 3.6 52.8 1.0 ND2 A:ASN209 3.7 34.7 1.0 CB A:ASP218 3.8 37.4 1.0 OD2 A:ASP208 4.0 39.1 1.0 O A:ASP208 4.0 39.1 1.0 O5' A:ADP1004 4.0 52.8 1.0 C5' A:ADP1004 4.2 52.8 1.0 O2B A:ADP1004 4.2 52.8 1.0 OD1 A:ASP218 4.2 37.4 1.0 CB A:ASN209 4.3 34.7 1.0 C A:ASP208 4.4 39.1 1.0 O3B A:ADP1004 4.4 52.8 1.0 CB A:ASP208 4.5 39.1 1.0 CA A:ASN209 4.5 34.7 1.0 N A:ASN209 4.7 34.7 1.0

Magnesium binding site 2 out of 3 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg705 b:54.6 occ:1.00 O3B E:ADP704 1.8 78.7 1.0 OG E:SER289 2.1 63.1 1.0 F3 E:AF3706 2.1 71.1 1.0 O2B E:ADP704 2.1 78.7 1.0 PB E:ADP704 2.3 78.7 1.0 AL E:AF3706 3.3 71.1 1.0 OE2 E:GLU375 3.3 62.0 1.0 O1A E:ADP704 3.3 78.7 1.0 CB E:SER289 3.4 63.1 1.0 O3A E:ADP704 3.5 78.7 1.0 O1B E:ADP704 3.5 78.7 1.0 PA E:ADP704 3.7 78.7 1.0 N E:SER289 3.8 63.1 1.0 O2A E:ADP704 3.9 78.7 1.0 F1 E:AF3706 4.0 71.1 1.0 CA E:SER289 4.2 63.1 1.0 OD1 E:ASP374 4.4 58.1 1.0 CA E:GLY538 4.4 81.3 1.0 CD E:GLU375 4.5 62.0 1.0 CB E:LYS288 4.7 61.5 1.0 F2 E:AF3706 4.7 71.1 1.0 CE E:LYS288 4.7 61.5 1.0 C E:LYS288 4.8 61.5 1.0 O E:GLY538 4.8 81.3 1.0 OD2 E:ASP374 4.9 58.1 1.0 NH1 E:ARG443 5.0 74.5 1.0

Magnesium binding site 3 out of 3 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range: probe atom residue distance (Å) B Occ F:Mg1004 b:121.4 occ:1.00 O3B F:ADP1003 1.8 150.4 1.0 OG F:SER289 2.1 138.1 1.0 F3 F:AF31005 2.1 141.0 1.0 O2B F:ADP1003 2.1 150.4 1.0 PB F:ADP1003 2.3 150.4 1.0 AL F:AF31005 3.3 141.0 1.0 OE2 F:GLU375 3.3 130.7 1.0 O2A F:ADP1003 3.3 150.4 1.0 CB F:SER289 3.4 138.1 1.0 O3A F:ADP1003 3.5 150.4 1.0 O1B F:ADP1003 3.5 150.4 1.0 PA F:ADP1003 3.7 150.4 1.0 N F:SER289 3.8 138.1 1.0 O1A F:ADP1003 3.9 150.4 1.0 F1 F:AF31005 4.0 141.0 1.0 CA F:SER289 4.2 138.1 1.0 OD1 F:ASP374 4.4 125.6 1.0 CA F:GLY538 4.4 149.2 1.0 CD F:GLU375 4.5 130.7 1.0 CB F:LYS288 4.7 140.3 1.0 F2 F:AF31005 4.7 141.0 1.0 CE F:LYS288 4.7 140.3 1.0 C F:LYS288 4.8 140.3 1.0 O F:GLY538 4.8 149.2 1.0 OD2 F:ASP374 5.0 125.6 1.0 NH1 F:ARG443 5.0 153.5 1.0

B.Malone, J.Chen, Q.Wang, E.C.Llewellyn, Y.J.Choi, P.D.B.Olinares, X.Cao, C.Hernandez, E.Eng, B.T.Chait, D.E.Shaw, R.Landick, S.A.Darst, E.A.Campbell. Structural Basis For Backtracking By the Sars-Cov-2 Replication-Transcription Complex Proc.Natl.Acad.Sci.Usa 2021.
ISSN: ESSN 1091-6490