Magnesium in PDB 7krz: Human Mitochondrial LONP1 in Complex with Bortezomib

All present enzymatic activity of Human Mitochondrial LONP1 in Complex with Bortezomib:
3.4.21.53;

The binding sites of Magnesium atom in the Human Mitochondrial LONP1 in Complex with Bortezomib (pdb code 7krz). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Human Mitochondrial LONP1 in Complex with Bortezomib, PDB code: 7krz:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in the Human Mitochondrial LONP1 in Complex with Bortezomib


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Mitochondrial LONP1 in Complex with Bortezomib within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1001 b:48.8 occ:1.00 O2B A:ATP1000 1.9 53.3 1.0 OG1 A:THR530 2.1 53.2 1.0 O1G A:ATP1000 2.5 53.3 1.0 CB A:THR530 3.0 53.2 1.0 PB A:ATP1000 3.4 53.3 1.0 PG A:ATP1000 3.6 53.3 1.0 OD1 A:ASP590 3.7 61.9 1.0 OD2 A:ASP590 3.8 61.9 1.0 CG2 A:THR530 3.8 53.2 1.0 O3G A:ATP1000 3.9 53.3 1.0 O3B A:ATP1000 3.9 53.3 1.0 OE2 A:GLU591 3.9 63.9 1.0 O1A A:ATP1000 4.0 53.3 1.0 NH2 B:ARG652 4.0 47.8 1.0 CG A:ASP590 4.2 61.9 1.0 CA A:THR530 4.2 53.2 1.0 O3A A:ATP1000 4.2 53.3 1.0 N A:THR530 4.2 53.2 1.0 CG2 A:THR638 4.2 56.8 1.0 O1B A:ATP1000 4.5 53.3 1.0 PA A:ATP1000 4.7 53.3 1.0 CD A:GLU591 4.8 63.9 1.0 O2G A:ATP1000 4.9 53.3 1.0

Magnesium binding site 2 out of 4 in the Human Mitochondrial LONP1 in Complex with Bortezomib


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human Mitochondrial LONP1 in Complex with Bortezomib within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1001 b:49.2 occ:1.00 OG1 B:THR530 2.0 48.8 1.0 O1B B:ATP1000 2.1 53.3 1.0 O1G B:ATP1000 2.1 53.3 1.0 CB B:THR530 3.2 48.8 1.0 PB B:ATP1000 3.4 53.3 1.0 PG B:ATP1000 3.5 53.3 1.0 O1A B:ATP1000 3.6 53.3 1.0 OE2 B:GLU591 3.7 51.1 1.0 OD1 B:ASP590 3.7 49.4 1.0 O3B B:ATP1000 3.8 53.3 1.0 OD2 B:ASP590 3.9 49.4 1.0 CG2 B:THR530 4.1 48.8 1.0 N B:THR530 4.2 48.8 1.0 CG B:ASP590 4.2 49.4 1.0 CA B:THR530 4.2 48.8 1.0 O3A B:ATP1000 4.4 53.3 1.0 O3G B:ATP1000 4.4 53.3 1.0 NH2 C:ARG652 4.4 43.2 1.0 O2G B:ATP1000 4.4 53.3 1.0 CD B:GLU591 4.5 51.1 1.0 O2B B:ATP1000 4.5 53.3 1.0 PA B:ATP1000 4.6 53.3 1.0 OD2 C:ASP612 4.8 49.4 1.0 OG1 B:THR638 4.8 45.5 1.0 OE1 B:GLU591 4.9 51.1 1.0

Magnesium binding site 3 out of 4 in the Human Mitochondrial LONP1 in Complex with Bortezomib


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Human Mitochondrial LONP1 in Complex with Bortezomib within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg1001 b:40.8 occ:1.00 O1G C:ATP1000 1.9 46.9 1.0 OG1 C:THR530 2.0 45.0 1.0 O2B C:ATP1000 2.1 46.9 1.0 CB C:THR530 3.2 45.0 1.0 PG C:ATP1000 3.3 46.9 1.0 PB C:ATP1000 3.4 46.9 1.0 O3B C:ATP1000 3.7 46.9 1.0 OD1 C:ASP590 3.8 47.3 1.0 OD2 C:ASP590 3.9 47.3 1.0 CG2 C:THR530 4.1 45.0 1.0 O3G C:ATP1000 4.1 46.9 1.0 O1A C:ATP1000 4.2 46.9 1.0 O3A C:ATP1000 4.2 46.9 1.0 N C:THR530 4.3 45.0 1.0 CG C:ASP590 4.3 47.3 1.0 CA C:THR530 4.3 45.0 1.0 O2G C:ATP1000 4.3 46.9 1.0 O1B C:ATP1000 4.5 46.9 1.0 NH2 D:ARG652 4.6 46.6 1.0 OD2 D:ASP612 4.8 51.2 1.0 OG1 C:THR638 4.8 42.2 1.0 PA C:ATP1000 4.8 46.9 1.0 OE1 C:GLU591 4.9 47.9 1.0

Magnesium binding site 4 out of 4 in the Human Mitochondrial LONP1 in Complex with Bortezomib


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Human Mitochondrial LONP1 in Complex with Bortezomib within 5.0Å range: probe atom residue distance (Å) B Occ D:Mg1001 b:59.5 occ:1.00 O3G D:ATP1000 2.0 55.7 1.0 OG1 D:THR530 2.4 53.9 1.0 O2B D:ATP1000 2.9 55.7 1.0 PG D:ATP1000 3.1 55.7 1.0 O1G D:ATP1000 3.3 55.7 1.0 OD1 D:ASP590 3.4 56.8 1.0 CB D:THR530 3.6 53.9 1.0 OD2 D:ASP590 3.9 56.8 1.0 O3B D:ATP1000 3.9 55.7 1.0 PB D:ATP1000 3.9 55.7 1.0 OG1 D:THR638 4.0 51.4 1.0 CG D:ASP590 4.1 56.8 1.0 O2G D:ATP1000 4.3 55.7 1.0 N D:THR530 4.3 53.9 1.0 CB D:THR638 4.4 51.4 1.0 CA D:THR530 4.5 53.9 1.0 CG2 D:THR530 4.5 53.9 1.0 O1B D:ATP1000 4.6 55.7 1.0 CE D:LYS529 4.7 50.7 1.0 CG2 D:THR638 4.7 51.4 1.0 CB D:LYS529 4.8 50.7 1.0 OE1 D:GLU591 5.0 59.2 1.0

M.Shin, E.R.Watson, A.S.Song, J.T.Mindrebo, S.R.Novick, P.Griffin, R.L.Wiseman, G.C.Lander. Human Mitochondrial LONP1 in Complex with Bortezomib To Be Published.