Magnesium in PDB 7m0x: Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901

All present enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901:
2.7.11.1; 2.7.12.2;

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901, PDB code: 7m0x was solved by K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.57 / 2.47
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	116.527, 116.527, 130.712, 90, 90, 120
R / Rfree (%)	17.8 / 21.5

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 also contains other interesting chemical elements:

Iodine	(I)	1 atom
Fluorine	(F)	3 atoms
Chlorine	(Cl)	1 atom

The binding sites of Magnesium atom in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 (pdb code 7m0x). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901, PDB code: 7m0x:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg802 b:38.7 occ:1.00 O1A A:ANP801 1.9 33.5 1.0 O1B A:ANP801 2.0 31.1 1.0 O2G A:ANP801 2.0 29.5 1.0 OD2 A:ASP594 2.1 38.9 1.0 O A:HOH911 2.1 36.8 1.0 OD1 A:ASN581 2.2 32.9 1.0 PB A:ANP801 3.0 31.4 1.0 PA A:ANP801 3.1 31.1 1.0 CG A:ASP594 3.2 45.9 1.0 CG A:ASN581 3.3 33.0 1.0 PG A:ANP801 3.3 34.6 1.0 O3A A:ANP801 3.4 34.5 1.0 N3B A:ANP801 3.7 31.8 1.0 NZ A:LYS483 3.8 36.6 1.0 O5' A:ANP801 3.8 38.3 1.0 ND2 A:ASN581 3.8 33.4 1.0 O A:HOH949 3.8 45.5 1.0 CB A:ASP594 4.1 35.9 1.0 OD1 A:ASP594 4.1 43.5 1.0 O1G A:ANP801 4.2 37.0 1.0 O A:ASN580 4.3 35.2 1.0 O2A A:ANP801 4.3 37.0 1.0 O2B A:ANP801 4.3 30.7 1.0 O3G A:ANP801 4.4 40.7 1.0 C8 A:ANP801 4.5 36.8 1.0 CB A:ASN581 4.5 28.9 1.0 CA A:ASN581 4.7 32.0 1.0 C A:ASN580 4.8 34.5 1.0 CE A:LYS483 4.9 34.4 1.0 N7 A:ANP801 5.0 37.1 1.0 N A:ASN581 5.0 29.2 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg802 b:38.9 occ:1.00 O B:HOH907 1.9 37.3 1.0 OD2 B:ASP208 2.0 40.8 1.0 O2A B:ANP801 2.0 38.3 1.0 OD1 B:ASN195 2.1 34.3 1.0 O1B B:ANP801 2.1 33.4 1.0 O B:HOH943 2.2 37.2 1.0 CG B:ASN195 3.1 33.7 1.0 CG B:ASP208 3.2 42.8 1.0 PA B:ANP801 3.2 36.1 1.0 PB B:ANP801 3.4 30.5 1.0 O3A B:ANP801 3.6 37.2 1.0 ND2 B:ASN195 3.6 36.5 1.0 O1G B:ANP801 3.7 42.5 1.0 O5' B:ANP801 3.9 39.3 1.0 NZ B:LYS97 3.9 46.3 1.0 CB B:ASP208 3.9 36.9 1.0 O17 B:4BM803 4.0 47.1 0.1 O B:SER194 4.0 34.8 1.0 O B:HOH939 4.2 40.9 1.0 OG B:SER194 4.2 37.2 1.0 OD1 B:ASP208 4.2 40.7 1.0 O2B B:ANP801 4.4 35.1 1.0 CB B:ASN195 4.4 32.5 1.0 O1A B:ANP801 4.5 45.7 1.0 N3B B:ANP801 4.5 36.7 1.0 C B:SER194 4.5 36.8 1.0 C19 B:4BM803 4.5 53.7 1.0 CA B:ASN195 4.6 35.8 1.0 PG B:ANP801 4.7 42.2 1.0 C18 B:4BM803 4.8 55.8 1.0 N B:ASN195 4.8 34.2 1.0 SG B:CYS207 4.8 42.6 0.8 CB B:SER194 4.9 34.5 1.0

K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck. Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 To Be Published.