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Magnesium in PDB 7nwm: Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12
Enzymatic activity of Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12
All present enzymatic activity of Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12:
2.6.1.42;
2.6.1.42;
Protein crystallography data
The structure of Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12, PDB code: 7nwm
was solved by
R.C.Hillig,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.84 / 2.15 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 66.3, 103.839, 107.816, 90, 90, 90 |
| R / Rfree (%) | 21.8 / 27.3 |
Other elements in 7nwm:
The structure of Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12 also contains other interesting chemical elements:
| Fluorine | (F) | 6 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12
(pdb code 7nwm). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12, PDB code: 7nwm:
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12, PDB code: 7nwm:
Magnesium binding site 1 out of 1 in 7nwm
Go back to
Magnesium Binding Sites List in 7nwm
Magnesium binding site 1 out
of 1 in the Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Structure of Human Cytosolic Branched-Chain Aminotransferase (BCAT1) in Complex with Plp and Inhibitor Compound 12 within 5.0Å range:
|
Reference:
J.Gunther,
R.C.Hillig,
K.Zimmermann,
S.Kaulfuss,
C.Lemos,
D.Nguyen,
H.Rehwinkel,
M.Habgood,
C.Lechner,
R.Neuhaus,
U.Ganzer,
M.Drewes,
J.Chai,
L.Bouche.
Bay-069, A Novel (Trifluoromethyl)Pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem. V. 65 14366 2022.
ISSN: ISSN 0022-2623
PubMed: 36261130
DOI: 10.1021/ACS.JMEDCHEM.2C00441
Page generated: Thu Oct 3 02:20:37 2024
ISSN: ISSN 0022-2623
PubMed: 36261130
DOI: 10.1021/ACS.JMEDCHEM.2C00441
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