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Magnesium in PDB 7oo7: KRASG12C Ligand ComplexEnzymatic activity of KRASG12C Ligand Complex
All present enzymatic activity of KRASG12C Ligand Complex:
3.6.5.2; Protein crystallography data
The structure of KRASG12C Ligand Complex, PDB code: 7oo7
was solved by
C.Phillips,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7oo7:
The structure of KRASG12C Ligand Complex also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the KRASG12C Ligand Complex
(pdb code 7oo7). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the KRASG12C Ligand Complex, PDB code: 7oo7: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 7oo7Go back to Magnesium Binding Sites List in 7oo7
Magnesium binding site 1 out
of 2 in the KRASG12C Ligand Complex
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 7oo7Go back to Magnesium Binding Sites List in 7oo7
Magnesium binding site 2 out
of 2 in the KRASG12C Ligand Complex
Mono view Stereo pair view
Reference:
J.G.Kettle,
S.K.Bagal,
S.Bickerton,
M.S.Bodnarchuk,
S.Boyd,
J.Breed,
R.J.Carbajo,
D.J.Cassar,
A.Chakraborty,
S.Cosulich,
I.Cumming,
M.Davies,
N.L.Davies,
A.Eatherton,
L.Evans,
L.Feron,
S.Fillery,
E.S.Gleave,
F.W.Goldberg,
L.Hanson,
S.Harlfinger,
M.Howard,
R.Howells,
A.Jackson,
P.Kemmitt,
G.Lamont,
S.Lamont,
H.J.Lewis,
L.Liu,
M.J.Niedbala,
C.Phillips,
R.Polanski,
P.Raubo,
G.Robb,
D.M.Robinson,
S.Ross,
M.G.Sanders,
M.Tonge,
R.Whiteley,
S.Wilkinson,
J.Yang,
W.Zhang.
Discovery of AZD4625, A Covalent Allosteric Inhibitor of the Mutant Gtpase Kras G12C . J.Med.Chem. V. 65 6940 2022.
Page generated: Thu Apr 6 18:15:09 2023
ISSN: ISSN 0022-2623 PubMed: 35471939 DOI: 10.1021/ACS.JMEDCHEM.2C00369 |
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