Magnesium in PDB 7pw7: Human SMG1-9 Kinase Complex Bound to A SMG1 Inhibitor

Enzymatic activity of Human SMG1-9 Kinase Complex Bound to A SMG1 Inhibitor

All present enzymatic activity of Human SMG1-9 Kinase Complex Bound to A SMG1 Inhibitor:
2.7.11.1;

Other elements in 7pw7:

The structure of Human SMG1-9 Kinase Complex Bound to A SMG1 Inhibitor also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Human SMG1-9 Kinase Complex Bound to A SMG1 Inhibitor (pdb code 7pw7). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human SMG1-9 Kinase Complex Bound to A SMG1 Inhibitor, PDB code: 7pw7:

Magnesium binding site 1 out of 1 in 7pw7

Go back to Magnesium Binding Sites List in 7pw7
Magnesium binding site 1 out of 1 in the Human SMG1-9 Kinase Complex Bound to A SMG1 Inhibitor


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human SMG1-9 Kinase Complex Bound to A SMG1 Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg602

b:70.8
occ:0.00
O3B C:ATP601 2.0 72.0 1.0
O2B C:ATP601 2.2 72.0 1.0
PG C:ATP601 2.4 72.0 1.0
PB C:ATP601 2.5 72.0 1.0
O1G C:ATP601 2.5 72.0 1.0
O3G C:ATP601 2.7 72.0 1.0
O3A C:ATP601 2.9 72.0 1.0
OG C:SER218 3.2 63.6 1.0
OG1 C:THR253 3.3 78.5 1.0
O1B C:ATP601 3.9 72.0 1.0
N C:SER218 3.9 63.6 1.0
CB C:THR253 3.9 78.5 1.0
O2G C:ATP601 3.9 72.0 1.0
CB C:SER218 4.0 63.6 1.0
O1A C:ATP601 4.1 72.0 1.0
PA C:ATP601 4.1 72.0 1.0
N C:LYS217 4.4 63.5 1.0
CB C:LYS217 4.4 63.5 1.0
N C:THR253 4.5 78.5 1.0
CA C:SER218 4.6 63.6 1.0
CG C:LYS217 4.7 63.5 1.0
CD C:LYS217 4.7 63.5 1.0
CA C:LYS217 4.8 63.5 1.0
O C:GLN213 4.8 79.3 1.0
C C:LYS217 4.8 63.5 1.0
CA C:THR253 4.9 78.5 1.0
CG2 C:THR253 5.0 78.5 1.0

Reference:

L.M.Langer, F.Bonneau, Y.Gat, E.Conti. Cryo-Em Reconstructions of Inhibitor-Bound SMG1 Kinase Reveal An Autoinhibitory State Dependent on SMG8. Elife V. 10 2021.
ISSN: ESSN 2050-084X
PubMed: 34698635
DOI: 10.7554/ELIFE.72353
Page generated: Fri Dec 17 10:52:36 2021

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