Magnesium in PDB 7pxg: Verruculogen-Bound Drosophila Slo Channel

The structure of Verruculogen-Bound Drosophila Slo Channel also contains other interesting chemical elements:

Potassium	(K)	4 atoms
Calcium	(Ca)	8 atoms

The binding sites of Magnesium atom in the Verruculogen-Bound Drosophila Slo Channel (pdb code 7pxg). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Verruculogen-Bound Drosophila Slo Channel, PDB code: 7pxg:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in the Verruculogen-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Verruculogen-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg2004 b:32.3 occ:1.00 O A:ASN523 2.3 39.0 1.0 O A:ALA526 2.4 43.8 1.0 O A:THR547 2.5 43.8 1.0 O A:MET549 2.8 48.4 1.0 CG A:GLU550 3.4 47.5 1.0 OE2 A:GLU550 3.5 47.5 1.0 C A:ASN523 3.6 39.0 1.0 C A:ALA526 3.6 43.8 1.0 C A:THR547 3.7 43.8 1.0 C A:MET549 3.7 48.4 1.0 CD A:GLU550 3.8 47.5 1.0 CG A:ARG528 3.9 49.0 1.0 CB A:ARG528 4.0 49.0 1.0 N A:ALA526 4.1 43.8 1.0 N A:ARG528 4.2 49.0 1.0 C A:GLY548 4.2 45.5 1.0 CA A:ALA526 4.3 43.8 1.0 CA A:GLU550 4.4 47.5 1.0 N A:GLU550 4.4 47.5 1.0 N A:MET549 4.4 48.4 1.0 O A:GLY548 4.4 45.5 1.0 CA A:LEU524 4.4 39.8 1.0 CA A:ASN523 4.4 39.0 1.0 N A:LEU524 4.5 39.8 1.0 CB A:GLU550 4.5 47.5 1.0 C A:LEU524 4.5 39.8 1.0 CA A:THR547 4.6 43.8 1.0 CA A:GLY548 4.6 45.5 1.0 CB A:ALA526 4.6 43.8 1.0 N A:GLY548 4.6 45.5 1.0 N A:MET527 4.7 48.7 1.0 CA A:ARG528 4.7 49.0 1.0 CA A:MET549 4.7 48.4 1.0 O A:LEU524 4.7 39.8 1.0 CB A:ASN523 4.8 39.0 1.0 N A:PHE525 4.8 40.6 1.0 C A:MET527 4.8 48.7 1.0 OE1 A:GLU550 4.8 47.5 1.0 CA A:MET527 4.8 48.7 1.0

Magnesium binding site 2 out of 4 in the Verruculogen-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Verruculogen-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg2004 b:33.0 occ:1.00 O B:ASN523 2.3 39.4 1.0 O B:ALA526 2.4 43.9 1.0 O B:THR547 2.5 45.0 1.0 O B:MET549 2.8 48.6 1.0 CG B:GLU550 3.4 48.2 1.0 OE2 B:GLU550 3.5 48.2 1.0 C B:ASN523 3.6 39.4 1.0 C B:ALA526 3.6 43.9 1.0 C B:THR547 3.7 45.0 1.0 C B:MET549 3.7 48.6 1.0 CD B:GLU550 3.8 48.2 1.0 CG B:ARG528 3.9 49.8 1.0 CB B:ARG528 4.0 49.8 1.0 N B:ALA526 4.1 43.9 1.0 N B:ARG528 4.2 49.8 1.0 C B:GLY548 4.2 46.8 1.0 CA B:ALA526 4.3 43.9 1.0 CA B:GLU550 4.4 48.2 1.0 N B:GLU550 4.4 48.2 1.0 N B:MET549 4.4 48.6 1.0 O B:GLY548 4.4 46.8 1.0 CA B:LEU524 4.4 39.9 1.0 CA B:ASN523 4.4 39.4 1.0 N B:LEU524 4.5 39.9 1.0 CB B:GLU550 4.5 48.2 1.0 C B:LEU524 4.5 39.9 1.0 CA B:THR547 4.6 45.0 1.0 CA B:GLY548 4.6 46.8 1.0 CB B:ALA526 4.6 43.9 1.0 N B:GLY548 4.6 46.8 1.0 N B:MET527 4.7 49.3 1.0 CA B:ARG528 4.7 49.8 1.0 CA B:MET549 4.7 48.6 1.0 O B:LEU524 4.7 39.9 1.0 CB B:ASN523 4.8 39.4 1.0 N B:PHE525 4.8 40.6 1.0 C B:MET527 4.8 49.3 1.0 OE1 B:GLU550 4.8 48.2 1.0 CA B:MET527 4.8 49.3 1.0

Magnesium binding site 3 out of 4 in the Verruculogen-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Verruculogen-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg1205 b:32.2 occ:1.00 O C:ASN523 2.3 39.9 1.0 O C:ALA526 2.4 43.7 1.0 O C:THR547 2.5 44.8 1.0 O C:MET549 2.8 49.1 1.0 CG C:GLU550 3.4 48.2 1.0 OE2 C:GLU550 3.5 48.2 1.0 C C:ASN523 3.6 39.9 1.0 C C:ALA526 3.6 43.7 1.0 C C:THR547 3.7 44.8 1.0 C C:MET549 3.7 49.1 1.0 CD C:GLU550 3.8 48.2 1.0 CG C:ARG528 3.9 50.8 1.0 CB C:ARG528 4.0 50.8 1.0 N C:ALA526 4.1 43.7 1.0 N C:ARG528 4.2 50.8 1.0 C C:GLY548 4.2 47.1 1.0 CA C:ALA526 4.3 43.7 1.0 CA C:GLU550 4.4 48.2 1.0 N C:GLU550 4.4 48.2 1.0 N C:MET549 4.4 49.1 1.0 O C:GLY548 4.4 47.1 1.0 CA C:LEU524 4.4 39.9 1.0 CA C:ASN523 4.4 39.9 1.0 N C:LEU524 4.5 39.9 1.0 CB C:GLU550 4.5 48.2 1.0 C C:LEU524 4.5 39.9 1.0 CA C:THR547 4.6 44.8 1.0 CA C:GLY548 4.6 47.1 1.0 CB C:ALA526 4.6 43.7 1.0 N C:GLY548 4.6 47.1 1.0 N C:MET527 4.7 49.2 1.0 CA C:ARG528 4.7 50.8 1.0 CA C:MET549 4.7 49.1 1.0 O C:LEU524 4.7 39.9 1.0 CB C:ASN523 4.8 39.9 1.0 N C:PHE525 4.8 40.0 1.0 C C:MET527 4.8 49.2 1.0 OE1 C:GLU550 4.8 48.2 1.0 CA C:MET527 4.8 49.2 1.0

Magnesium binding site 4 out of 4 in the Verruculogen-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Verruculogen-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Mg2004 b:33.5 occ:1.00 O D:ASN523 2.3 40.4 1.0 O D:ALA526 2.4 44.5 1.0 O D:THR547 2.5 45.7 1.0 O D:MET549 2.8 50.3 1.0 CG D:GLU550 3.4 48.6 1.0 OE2 D:GLU550 3.5 48.6 1.0 C D:ASN523 3.6 40.4 1.0 C D:ALA526 3.6 44.5 1.0 C D:THR547 3.7 45.7 1.0 C D:MET549 3.7 50.3 1.0 CD D:GLU550 3.8 48.6 1.0 CG D:ARG528 3.9 50.1 1.0 CB D:ARG528 4.0 50.1 1.0 N D:ALA526 4.1 44.5 1.0 N D:ARG528 4.2 50.1 1.0 C D:GLY548 4.2 47.9 1.0 CA D:ALA526 4.3 44.5 1.0 CA D:GLU550 4.4 48.6 1.0 N D:GLU550 4.4 48.6 1.0 N D:MET549 4.4 50.3 1.0 O D:GLY548 4.4 47.9 1.0 CA D:LEU524 4.4 40.3 1.0 CA D:ASN523 4.4 40.4 1.0 N D:LEU524 4.5 40.3 1.0 CB D:GLU550 4.5 48.6 1.0 C D:LEU524 4.5 40.3 1.0 CA D:THR547 4.6 45.7 1.0 CA D:GLY548 4.6 47.9 1.0 CB D:ALA526 4.6 44.5 1.0 N D:GLY548 4.6 47.9 1.0 N D:MET527 4.7 49.8 1.0 CA D:ARG528 4.7 50.1 1.0 CA D:MET549 4.7 50.3 1.0 O D:LEU524 4.7 40.3 1.0 CB D:ASN523 4.8 40.4 1.0 N D:PHE525 4.8 41.1 1.0 C D:MET527 4.8 49.8 1.0 OE1 D:GLU550 4.8 48.6 1.0 CA D:MET527 4.8 49.8 1.0

T.Raisch, A.Brockmann, U.Ebbinghaus-Kintscher, J.Freigang, O.Gutbrod, J.Kubicek, B.Maertens, O.Hofnagel, S.Raunser. Small Molecule Modulation of the Drosophila Slo Channel Elucidated By Cryo-Em To Be Published.
DOI: 10.1038/S41467-021-27435-W