Magnesium in PDB 7qfn: Human Topoisomerase II Beta Atpase Adp

All present enzymatic activity of Human Topoisomerase II Beta Atpase Adp:
5.6.2.2;

The structure of Human Topoisomerase II Beta Atpase Adp, PDB code: 7qfn was solved by E.M.Ling, A.Basle, I.G.Cowell, T.R.Blower, C.A.Austin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	89.22 / 2.62
Space group	P 3 2 1
Cell size a, b, c (Å), α, β, γ (°)	103.021, 103.021, 66.693, 90, 90, 120
R / Rfree (%)	20.7 / 25.1

The binding sites of Magnesium atom in the Human Topoisomerase II Beta Atpase Adp (pdb code 7qfn). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human Topoisomerase II Beta Atpase Adp, PDB code: 7qfn:

Magnesium binding site 1 out of 1 in the Human Topoisomerase II Beta Atpase Adp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Topoisomerase II Beta Atpase Adp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg504 b:42.0 occ:1.00 O2A A:ADP501 2.1 46.9 1.0 OD1 A:ASN107 2.2 50.0 1.0 O3B A:ADP501 2.3 47.4 1.0 OE2 A:GLU103 3.0 71.5 1.0 CG A:ASN107 3.2 46.6 1.0 HD21 A:ASN107 3.3 52.0 1.0 PB A:ADP501 3.4 43.1 1.0 PA A:ADP501 3.5 44.8 1.0 O1B A:ADP501 3.5 54.6 1.0 HA2 A:GLY177 3.6 56.6 1.0 ND2 A:ASN107 3.6 54.7 1.0 HA3 A:GLY182 3.8 45.9 1.0 O A:GLU103 3.8 43.6 1.0 O3 A:SO4502 3.9 75.3 1.0 O3A A:ADP501 3.9 40.2 1.0 HA3 A:GLY177 4.0 56.6 1.0 HA A:ASN107 4.2 43.2 1.0 CA A:GLY177 4.3 54.5 1.0 CD A:GLU103 4.3 64.6 1.0 O5' A:ADP501 4.4 42.0 1.0 CB A:ASN107 4.4 42.7 1.0 H A:ALA183 4.4 50.3 1.0 HD22 A:ASN107 4.5 52.0 1.0 HA A:GLU103 4.5 42.1 1.0 O1A A:ADP501 4.6 46.1 1.0 O A:TYR181 4.6 69.0 1.0 OD2 A:ASP110 4.6 57.5 1.0 HG11 A:VAL106 4.6 40.1 1.0 HB3 A:GLU103 4.6 45.0 1.0 H A:ASN107 4.7 42.9 1.0 CA A:ASN107 4.7 42.8 1.0 N A:ASN107 4.8 43.1 1.0 CA A:GLY182 4.8 43.3 1.0 O2B A:ADP501 4.8 35.2 1.0 HB A:VAL106 4.8 41.0 1.0 N A:GLY177 4.8 63.5 1.0 C A:GLU103 4.8 44.6 1.0 HB2 A:ASN107 4.8 43.6 1.0 H A:GLY177 4.9 60.4 1.0

E.M.Ling, A.Basle, I.G.Cowell, B.Van Den Berg, T.R.Blower, C.A.Austin. A Comprehensive Structural Analysis of the Atpase Domain of Human Dna Topoisomerase II Beta Bound to Amppnp, Adp, and the Bisdioxopiperazine, ICRF193. Structure V. 30 1129 2022.
ISSN: ISSN 0969-2126
PubMed: 35660158
DOI: 10.1016/J.STR.2022.05.009