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Magnesium in PDB 7rpz: Kras G12D in Complex with Mrtx-1133Enzymatic activity of Kras G12D in Complex with Mrtx-1133
All present enzymatic activity of Kras G12D in Complex with Mrtx-1133:
3.6.5.2; Protein crystallography data
The structure of Kras G12D in Complex with Mrtx-1133, PDB code: 7rpz
was solved by
R.J.Gunn,
N.C.Thomas,
W.Xiaolun,
J.D.Lawson,
M.A.Marx,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7rpz:
The structure of Kras G12D in Complex with Mrtx-1133 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Kras G12D in Complex with Mrtx-1133
(pdb code 7rpz). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Kras G12D in Complex with Mrtx-1133, PDB code: 7rpz: Magnesium binding site 1 out of 1 in 7rpzGo back to Magnesium Binding Sites List in 7rpz
Magnesium binding site 1 out
of 1 in the Kras G12D in Complex with Mrtx-1133
Mono view Stereo pair view
Reference:
X.Wang,
S.Allen,
J.F.Blake,
V.Bowcut,
D.M.Briere,
A.Calinisan,
J.R.Dahlke,
J.B.Fell,
J.P.Fischer,
R.J.Gunn,
J.Hallin,
J.Laguer,
J.D.Lawson,
J.Medwid,
B.Newhouse,
P.Nguyen,
J.M.O'leary,
P.Olson,
S.Pajk,
L.Rahbaek,
M.Rodriguez,
C.R.Smith,
T.P.Tang,
N.C.Thomas,
D.Vanderpool,
G.P.Vigers,
J.G.Christensen,
M.A.Marx.
Identification of MRTX1133, A Noncovalent, Potent, and Selective Kras G12D Inhibitor. J.Med.Chem. 2021.
Page generated: Fri Dec 24 09:28:58 2021
ISSN: ISSN 0022-2623 PubMed: 34889605 DOI: 10.1021/ACS.JMEDCHEM.1C01688 |
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