Magnesium in PDB 7ruv: Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin

Enzymatic activity of Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin

All present enzymatic activity of Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin:
2.5.1.17;

Protein crystallography data

The structure of Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin, PDB code: 7ruv was solved by R.Mascarenhas, H.Gouda, M.Koutmos, R.Banerjee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.00 / 2.10
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 121.181, 121.181, 169.77, 90, 90, 120
R / Rfree (%) 18.5 / 21.7

Other elements in 7ruv:

The structure of Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin also contains other interesting chemical elements:

Cobalt (Co) 4 atoms
Potassium (K) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin (pdb code 7ruv). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin, PDB code: 7ruv:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 7ruv

Go back to Magnesium Binding Sites List in 7ruv
Magnesium binding site 1 out of 2 in the Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg302

b:45.5
occ:0.33
NZ A:LYS177 4.0 71.8 1.0
CZ A:PHE98 4.2 42.3 1.0
CD A:LYS177 4.3 61.5 1.0
CD2 A:LEU102 4.3 48.2 1.0
CE A:LYS177 4.8 65.9 1.0
CE1 A:PHE98 4.8 42.3 1.0

Magnesium binding site 2 out of 2 in 7ruv

Go back to Magnesium Binding Sites List in 7ruv
Magnesium binding site 2 out of 2 in the Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of Human Atp:Cobalamin Adenosyltransferase E193K Bound to Adenosylcobalamin within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg502

b:36.6
occ:1.00
NH1 C:ARG195 3.1 36.4 1.0
O C:HOH614 3.3 39.5 1.0
CD C:ARG191 3.9 37.8 1.0
CZ C:ARG195 4.3 45.4 1.0
NH2 C:ARG191 4.3 33.0 1.0
OE2 C:GLU84 4.4 47.3 1.0
NE C:ARG191 4.5 38.3 1.0
NE C:ARG195 4.6 42.0 1.0
CZ C:ARG191 4.7 39.9 1.0
CG C:ARG191 4.9 38.5 1.0

Reference:

H.Gouda, R.Mascarenhas, S.Pillay, M.Ruetz, M.Koutmos, R.Banerjee. Patient Mutations in Human Atp:Cob(I)Alamin Adenosyltransferase Differentially Affect Its Catalytic Versus Chaperone Functions. J.Biol.Chem. 01373 2021.
ISSN: ESSN 1083-351X
PubMed: 34757128
DOI: 10.1016/J.JBC.2021.101373
Page generated: Thu Nov 25 10:09:45 2021

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