Magnesium in PDB 7sv7: The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661)

All present enzymatic activity of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661):
5.6.1.6;

The structure of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661) also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

The binding sites of Magnesium atom in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661) (pdb code 7sv7). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661), PDB code: 7sv7:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1501 b:74.0 occ:1.00 OE1 A:GLN493 2.0 71.3 1.0 O2B A:ATP1503 2.1 77.1 1.0 O3G A:ATP1503 2.3 77.1 1.0 OG1 A:THR465 2.3 73.0 1.0 CD A:GLN493 2.6 71.3 1.0 NE2 A:GLN493 2.7 71.3 1.0 PB A:ATP1503 3.0 77.1 1.0 O1B A:ATP1503 3.3 77.1 1.0 PG A:ATP1503 3.4 77.1 1.0 O3B A:ATP1503 3.5 77.1 1.0 CB A:THR465 3.6 73.0 1.0 O1G A:ATP1503 3.9 77.1 1.0 CG A:GLN493 4.0 71.3 1.0 N A:THR465 4.2 73.0 1.0 CA A:THR465 4.5 73.0 1.0 O3A A:ATP1503 4.5 77.1 1.0 CB A:GLN493 4.5 71.3 1.0 OD1 A:ASP572 4.6 75.2 1.0 CG2 A:THR465 4.6 73.0 1.0 OD2 A:ASP572 4.6 75.2 1.0 O2G A:ATP1503 4.6 77.1 1.0 O2A A:ATP1503 4.7 77.1 1.0 CB A:HIS1348 5.0 72.4 1.0

Magnesium binding site 2 out of 2 in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1502 b:68.3 occ:1.00 O3G A:ATP1504 2.0 74.3 1.0 OG A:SER1251 2.3 71.4 1.0 OE1 A:GLN1291 2.3 68.8 1.0 O2B A:ATP1504 2.4 74.3 1.0 O3B A:ATP1504 2.8 74.3 1.0 PG A:ATP1504 3.0 74.3 1.0 PB A:ATP1504 3.2 74.3 1.0 CD A:GLN1291 3.3 68.8 1.0 CB A:SER1251 3.3 71.4 1.0 NE2 A:GLN1291 3.6 68.8 1.0 O2G A:ATP1504 3.9 74.3 1.0 O2A A:ATP1504 3.9 74.3 1.0 O1G A:ATP1504 4.1 74.3 1.0 OD1 A:ASP1370 4.1 73.1 1.0 N A:SER1251 4.2 71.4 1.0 O3A A:ATP1504 4.2 74.3 1.0 O1B A:ATP1504 4.3 74.3 1.0 CA A:SER1251 4.3 71.4 1.0 OD2 A:ASP1370 4.4 73.1 1.0 N A:GLY550 4.5 71.2 1.0 PA A:ATP1504 4.6 74.3 1.0 CG A:GLN1291 4.6 68.8 1.0 CG A:ASP1370 4.7 73.1 1.0 CB A:GLN1291 5.0 68.8 1.0 CB A:SER549 5.0 70.4 1.0

K.Fiedorczuk, J.Chen. Mechanism of Cftr Correction By Type I Folding Correctors. Cell V. 185 158 2022.
ISSN: ISSN 1097-4172
PubMed: 34995514
DOI: 10.1016/J.CELL.2021.12.009