Magnesium in PDB 7svd: The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809)

All present enzymatic activity of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809):
5.6.1.6;

The structure of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809) also contains other interesting chemical elements:

Fluorine

(F)

2 atoms

The binding sites of Magnesium atom in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809) (pdb code 7svd). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809), PDB code: 7svd:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1501 b:58.2 occ:1.00 O A:HOH1601 2.0 56.5 1.0 O A:HOH1602 2.0 56.1 1.0 OE1 A:GLN493 2.1 56.9 1.0 OG1 A:THR465 2.1 53.4 1.0 O2B A:ATP1503 2.2 56.6 1.0 O3G A:ATP1503 2.2 56.6 1.0 CD A:GLN493 3.2 56.9 1.0 CB A:THR465 3.3 53.4 1.0 PG A:ATP1503 3.3 56.6 1.0 O1G A:ATP1503 3.6 56.6 1.0 PB A:ATP1503 3.6 56.6 1.0 NE2 A:GLN493 3.6 56.9 1.0 O2A A:ATP1503 3.8 56.6 1.0 O3B A:ATP1503 3.9 56.6 1.0 N A:THR465 4.1 53.4 1.0 OD2 A:ASP572 4.2 55.9 1.0 CA A:THR465 4.3 53.4 1.0 CG2 A:THR465 4.3 53.4 1.0 OD1 A:ASP572 4.5 55.9 1.0 CG A:GLN493 4.5 56.9 1.0 O3A A:ATP1503 4.5 56.6 1.0 PA A:ATP1503 4.5 56.6 1.0 O1B A:ATP1503 4.6 56.6 1.0 O2G A:ATP1503 4.7 56.6 1.0 O1A A:ATP1503 4.7 56.6 1.0 CB A:HIS1348 4.8 59.7 1.0 CB A:GLN493 4.8 56.9 1.0 CG A:ASP572 4.8 55.9 1.0

Magnesium binding site 2 out of 2 in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Lumacaftor (Vx-809) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1502 b:49.7 occ:1.00 OE1 A:GLN1291 2.1 57.4 1.0 OG A:SER1251 2.1 51.2 1.0 O2B A:ATP1504 2.2 52.4 1.0 O3G A:ATP1504 2.2 52.4 1.0 CD A:GLN1291 3.2 57.4 1.0 CB A:SER1251 3.2 51.2 1.0 PG A:ATP1504 3.6 52.4 1.0 NE2 A:GLN1291 3.6 57.4 1.0 PB A:ATP1504 3.6 52.4 1.0 O2A A:ATP1504 3.8 52.4 1.0 O3B A:ATP1504 4.0 52.4 1.0 O1G A:ATP1504 4.1 52.4 1.0 N A:SER1251 4.1 51.2 1.0 CA A:SER1251 4.2 51.2 1.0 OD2 A:ASP1370 4.4 59.0 1.0 OD1 A:ASP1370 4.4 59.0 1.0 O3A A:ATP1504 4.5 52.4 1.0 CG A:GLN1291 4.5 57.4 1.0 PA A:ATP1504 4.6 52.4 1.0 O1B A:ATP1504 4.7 52.4 1.0 O2G A:ATP1504 4.7 52.4 1.0 CG A:ASP1370 4.8 59.0 1.0 N A:GLY550 4.8 51.0 1.0 CB A:SER549 4.9 49.9 1.0 CB A:GLN1291 4.9 57.4 1.0

K.Fiedorczuk, J.Chen. Mechanism of Cftr Correction By Type I Folding Correctors. Cell V. 185 158 2022.
ISSN: ISSN 1097-4172
PubMed: 34995514
DOI: 10.1016/J.CELL.2021.12.009