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Atomistry » Magnesium » PDB 7t21-7tgn » 7t47 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 7t21-7tgn » 7t47 » |
Magnesium in PDB 7t47: Kras G12D (Gppcp) with Mrtx-1133Enzymatic activity of Kras G12D (Gppcp) with Mrtx-1133
All present enzymatic activity of Kras G12D (Gppcp) with Mrtx-1133:
3.6.5.2; Protein crystallography data
The structure of Kras G12D (Gppcp) with Mrtx-1133, PDB code: 7t47
was solved by
N.C.Thomas,
R.J.Gunn,
J.D.Lawson,
X.Wang,
M.A.Matthew,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7t47:
The structure of Kras G12D (Gppcp) with Mrtx-1133 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Kras G12D (Gppcp) with Mrtx-1133
(pdb code 7t47). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Kras G12D (Gppcp) with Mrtx-1133, PDB code: 7t47: Magnesium binding site 1 out of 1 in 7t47Go back to Magnesium Binding Sites List in 7t47
Magnesium binding site 1 out
of 1 in the Kras G12D (Gppcp) with Mrtx-1133
Mono view Stereo pair view
Reference:
J.Christensen,
J.Hallin,
V.Bowcut,
A.Calinsan,
D.Briere,
L.Hargis,
L.Engstrom,
J.Laguer,
J.Medwid,
D.Vanderpool,
E.Lifset,
D.Trinh,
N.Hoffman,
X.Wang,
J.Lawson,
R.Gunn,
C.Smith,
N.Thomas,
M.Martinson,
A.Bergstrom,
F.Sullivan,
K.Bouhana,
S.Winski,
L.He,
F.B.Julio,
A.Pavlicek,
J.Hafing,
L.Rahbaek,
M.Marx,
P.Olson.
A Non-Covalent KRASG12D Allele Specific Inhibitor Demonstrates Potent Inhibition of Kras-Dependent Signaling and Regression of KRASG12D-Mutant Tumors Nature 2022.
Page generated: Thu Oct 3 09:02:30 2024
ISSN: ESSN 1476-4687 DOI: 10.21203/RS.3.RS-1261963/V1 |
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