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Magnesium in PDB 7vke: Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A

Enzymatic activity of Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A

All present enzymatic activity of Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A:
2.4.99.20; 3.2.2.6;

Protein crystallography data

The structure of Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A, PDB code: 7vke was solved by W.V.Schooten, U.Schellenberger, H.S.Ugamraj, S.Manicka, S.Bijpuria, R.K.Gondu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.08 / 1.90
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 64.82, 64.82, 201.316, 90, 90, 120
R / Rfree (%) 19.3 / 23.1

Other elements in 7vke:

The structure of Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A also contains other interesting chemical elements:

Sodium (Na) 1 atom
Chlorine (Cl) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A (pdb code 7vke). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A, PDB code: 7vke:

Magnesium binding site 1 out of 1 in 7vke

Go back to Magnesium Binding Sites List in 7vke
Magnesium binding site 1 out of 1 in the Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human CD38 Ecd in Complex with Unidab(Tm) F11A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg405

b:39.6
occ:1.00
 O A:HOH519 2.4 58.3 1.0
N A:PHE222 3.0 30.9 1.0
O A:HOH654 3.1 51.0 1.0
OG A:SER126 3.3 36.5 1.0
CB A:SER220 3.4 37.0 1.0
N A:THR221 3.4 29.7 1.0
CB A:PHE222 3.5 27.5 1.0
OG A:SER220 3.7 31.2 1.0
O A:HOH515 3.7 47.1 1.0
CA A:PHE222 3.8 28.7 1.0
CB A:SER126 3.8 31.1 1.0
O A:HOH590 3.8 35.6 1.0
C A:THR221 3.9 31.3 1.0
CA A:THR221 3.9 31.4 1.0
CB A:THR221 4.0 35.5 1.0
O A:TRP125 4.0 19.8 1.0
CA A:SER126 4.0 27.2 1.0
C A:SER220 4.1 31.3 1.0
O A:HOH576 4.1 38.6 1.0
CA A:SER220 4.2 34.9 1.0
OG1 A:THR221 4.7 39.6 1.0
C A:TRP125 4.8 21.1 1.0
N A:SER126 4.9 24.4 1.0
CG A:PHE222 4.9 26.3 1.0
C A:PHE222 4.9 30.5 1.0
N A:GLY223 5.0 26.1 1.0

Reference:

H.S.Ugamraj, K.Dang, L.H.Ouisse, B.Buelow, E.N.Chini, G.Castello, J.Allison, S.C.Clarke, L.M.Davison, R.Buelow, R.Deng, S.Iyer, U.Schellenberger, S.N.Manika, S.Bijpuria, A.Musnier, A.Poupon, M.C.Cuturi, W.Van Schooten, P.Dalvi. Tnb-738, A Biparatopic Antibody, Boosts Intracellular Nad+ By Inhibiting CD38 Ecto-Enzyme Activity. Mabs V. 14 95949 2022.
ISSN: ESSN 1942-0870
PubMed: 35867844
DOI: 10.1080/19420862.2022.2095949
Page generated: Thu Oct 3 10:31:13 2024

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