Magnesium in PDB 7w02: Cryo-Em Structure of Atp-Bound ABCA3

All present enzymatic activity of Cryo-Em Structure of Atp-Bound ABCA3:
7.6.2.1; 7.6.2.2;

The binding sites of Magnesium atom in the Cryo-Em Structure of Atp-Bound ABCA3 (pdb code 7w02). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cryo-Em Structure of Atp-Bound ABCA3, PDB code: 7w02:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cryo-Em Structure of Atp-Bound ABCA3


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of Atp-Bound ABCA3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1803 b:42.8 occ:1.00 OE1 A:GLN613 1.9 37.9 1.0 O2B A:ATP1801 2.0 47.2 1.0 OG1 A:THR573 2.1 35.1 1.0 O3G A:ATP1801 2.2 47.2 1.0 CD A:GLN613 3.0 37.9 1.0 PB A:ATP1801 3.1 47.2 1.0 CB A:THR573 3.3 35.1 1.0 PG A:ATP1801 3.5 47.2 1.0 O1B A:ATP1801 3.7 47.2 1.0 O3B A:ATP1801 3.7 47.2 1.0 NE2 A:GLN613 3.7 37.9 1.0 CG2 A:THR573 3.9 35.1 1.0 OD2 A:ASP689 4.1 41.1 1.0 CG A:GLN613 4.1 37.9 1.0 O1G A:ATP1801 4.4 47.2 1.0 CA A:THR573 4.5 35.1 1.0 O3A A:ATP1801 4.5 47.2 1.0 O2G A:ATP1801 4.5 47.2 1.0 O1A A:ATP1801 4.6 47.2 1.0 OD1 A:ASP689 4.6 41.1 1.0 NE2 A:GLN690 4.6 42.2 1.0 CB A:GLN613 4.6 37.9 1.0 N A:THR573 4.7 35.1 1.0 O A:LYS572 4.7 38.6 1.0 CG A:ASP689 4.7 41.1 1.0 C A:LYS572 4.9 38.6 1.0 PA A:ATP1801 4.9 47.2 1.0

Magnesium binding site 2 out of 2 in the Cryo-Em Structure of Atp-Bound ABCA3


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of Atp-Bound ABCA3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1804 b:63.6 occ:1.00 OG1 A:THR1423 2.1 65.4 1.0 O2B A:ATP1802 2.1 69.8 1.0 OE1 A:GLN1463 2.1 50.5 1.0 O2G A:ATP1802 2.2 69.8 1.0 CD A:GLN1463 2.9 50.5 1.0 PG A:ATP1802 3.1 69.8 1.0 NE2 A:GLN1463 3.1 50.5 1.0 O3G A:ATP1802 3.2 69.8 1.0 PB A:ATP1802 3.3 69.8 1.0 CB A:THR1423 3.3 65.4 1.0 O3B A:ATP1802 3.4 69.8 1.0 CG2 A:THR1423 4.1 65.4 1.0 OE1 A:GLN1540 4.1 53.7 1.0 NE2 A:GLN1540 4.2 53.7 1.0 N A:THR1423 4.2 65.4 1.0 O1B A:ATP1802 4.3 69.8 1.0 CA A:THR1423 4.3 65.4 1.0 O3A A:ATP1802 4.4 69.8 1.0 CG A:GLN1463 4.4 50.5 1.0 O1G A:ATP1802 4.5 69.8 1.0 CD A:GLN1540 4.6 53.7 1.0 O1A A:ATP1802 4.7 69.8 1.0 OD1 A:ASP1539 4.7 54.3 1.0 CB A:GLN1463 4.8 50.5 1.0 O A:SER666 4.9 58.0 1.0

T.Xie, Z.Zhang, J.Yue, Q.Fang, X.Gong. Cryo-Em Structures of the Human Surfactant Lipid Transporter ABCA3. Sci Adv V. 8 N3727 2022.
ISSN: ESSN 2375-2548
PubMed: 35394827
DOI: 10.1126/SCIADV.ABN3727