Magnesium in PDB 7wc9: Crystal Structure of Serotonin 2A Receptor in Complex with Non- Hallucinogenic Psychedelic Analog

The structure of Crystal Structure of Serotonin 2A Receptor in Complex with Non- Hallucinogenic Psychedelic Analog, PDB code: 7wc9 was solved by D.Cao, J.Yu, H.Wang, Z.Luo, X.Liu, L.He, J.Qi, L.Fan, L.Tang, Z.Chen, J.Li, J.Cheng, S.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.80 / 2.50
Space group	P 21 2 21
Cell size a, b, c (Å), α, β, γ (°)	49.53, 54.95, 179.88, 90, 90, 90
R / Rfree (%)	24.4 / 26.6

The binding sites of Magnesium atom in the Crystal Structure of Serotonin 2A Receptor in Complex with Non- Hallucinogenic Psychedelic Analog (pdb code 7wc9). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Serotonin 2A Receptor in Complex with Non- Hallucinogenic Psychedelic Analog, PDB code: 7wc9:

Magnesium binding site 1 out of 1 in the Crystal Structure of Serotonin 2A Receptor in Complex with Non- Hallucinogenic Psychedelic Analog


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Serotonin 2A Receptor in Complex with Non- Hallucinogenic Psychedelic Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1201 b:22.9 occ:0.50 OE2 A:GLU1008 1.9 64.5 1.0 OD2 A:ASP1012 2.0 56.8 1.0 CG A:ASP1012 2.8 62.6 1.0 CD A:GLU1008 2.8 73.8 1.0 OD1 A:ASP1012 2.9 57.9 1.0 CG A:GLU1008 3.1 72.5 1.0 OE1 A:GLU1008 3.9 66.2 1.0 CB A:ASP1012 4.2 55.0 1.0 O A:GLU1008 4.4 61.0 1.0 CB A:GLU1008 4.6 59.9 1.0

D.Cao, J.Yu, H.Wang, Z.Luo, X.Liu, L.He, J.Qi, L.Fan, L.Tang, Z.Chen, J.Li, J.Cheng, S.Wang. Structure-Based Discovery of Nonhallucinogenic Psychedelic Analogs. Science V. 375 403 2022.
ISSN: ESSN 1095-9203
PubMed: 35084960
DOI: 10.1126/SCIENCE.ABL8615