Magnesium in PDB 7wyx: Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime

The structure of Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Magnesium atom in the Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime (pdb code 7wyx). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime, PDB code: 7wyx:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1101 b:66.3 occ:1.00 OP3 A:PHD376 1.9 57.7 1.0 O A:HOH1202 2.0 61.6 1.0 O A:THR378 2.0 61.4 1.0 OD1 A:ASP717 2.1 60.7 1.0 O A:HOH1203 2.2 65.0 1.0 OD2 A:PHD376 2.3 57.7 1.0 CG A:ASP717 3.0 60.7 1.0 C A:THR378 3.2 61.4 1.0 CG A:PHD376 3.2 57.7 1.0 OD2 A:ASP717 3.2 60.7 1.0 P A:PHD376 3.2 57.7 1.0 OD1 A:PHD376 3.5 57.7 1.0 OD2 A:ASP721 3.9 64.9 1.0 N A:GLY718 4.0 64.6 1.0 CB A:THR378 4.0 61.4 1.0 OP1 A:PHD376 4.0 57.7 1.0 CA A:THR378 4.0 61.4 1.0 N A:GLY379 4.1 57.5 1.0 OP2 A:PHD376 4.3 57.7 1.0 CG2 A:THR378 4.3 61.4 1.0 CA A:GLY379 4.3 57.5 1.0 N A:THR378 4.4 61.4 1.0 CB A:ASP717 4.4 60.7 1.0 OD1 A:ASN720 4.5 69.1 1.0 CB A:PHD376 4.5 57.7 1.0 N A:ASP717 4.5 60.7 1.0 OG1 A:THR380 4.6 57.1 1.0 CA A:GLY718 4.6 64.6 1.0 ND2 A:ASN720 4.7 69.1 1.0 CA A:ASP717 4.8 60.7 1.0 C A:ASP717 4.8 60.7 1.0 O A:SER216 4.9 94.0 1.0 N A:THR380 4.9 57.1 1.0 C A:GLY379 4.9 57.5 1.0 CG A:ASP721 4.9 64.9 1.0

Magnesium binding site 2 out of 2 in the Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of Na+,K+-Atpase in the E2P State Formed By Atp with Istaroxime within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg1101 b:66.7 occ:1.00 OP3 C:PHD376 1.9 57.8 1.0 O C:HOH1202 2.0 61.8 1.0 O C:THR378 2.0 61.6 1.0 OD1 C:ASP717 2.1 60.8 1.0 O C:HOH1203 2.2 65.3 1.0 OD2 C:PHD376 2.3 57.8 1.0 CG C:ASP717 3.0 60.8 1.0 C C:THR378 3.2 61.6 1.0 CG C:PHD376 3.2 57.8 1.0 OD2 C:ASP717 3.2 60.8 1.0 P C:PHD376 3.2 57.8 1.0 OD1 C:PHD376 3.5 57.8 1.0 OD2 C:ASP721 3.9 65.1 1.0 N C:GLY718 4.0 64.7 1.0 CB C:THR378 4.0 61.6 1.0 OP1 C:PHD376 4.0 57.8 1.0 CA C:THR378 4.0 61.6 1.0 N C:GLY379 4.1 57.7 1.0 OP2 C:PHD376 4.3 57.8 1.0 CG2 C:THR378 4.3 61.6 1.0 CA C:GLY379 4.3 57.7 1.0 N C:THR378 4.4 61.6 1.0 CB C:ASP717 4.4 60.8 1.0 OD1 C:ASN720 4.5 69.3 1.0 CB C:PHD376 4.5 57.8 1.0 N C:ASP717 4.5 60.8 1.0 OG1 C:THR380 4.6 57.5 1.0 CA C:GLY718 4.6 64.7 1.0 ND2 C:ASN720 4.7 69.3 1.0 CA C:ASP717 4.8 60.8 1.0 C C:ASP717 4.8 60.8 1.0 O C:SER216 4.9 94.6 1.0 N C:THR380 4.9 57.5 1.0 C C:GLY379 4.9 57.7 1.0 CG C:ASP721 4.9 65.1 1.0

R.Kanai, F.Cornelius, B.Vilsen, C.Toyoshima. Cryoelectron Microscopy of Na + ,K + -Atpase in the Two E2P States with and Without Cardiotonic Steroids. Proc.Natl.Acad.Sci.Usa V. 119 26119 2022.
ISSN: ESSN 1091-6490
PubMed: 35380894
DOI: 10.1073/PNAS.2123226119