Magnesium in PDB 7zvn: Crystal Structure of Human Annexin A2 in Complex with Full Phosphorothioate 5-10 2'-Methoxyethyl Dna Gapmer Antisense Oligonucleotide Solved at 1.87 A Resolution

The structure of Crystal Structure of Human Annexin A2 in Complex with Full Phosphorothioate 5-10 2'-Methoxyethyl Dna Gapmer Antisense Oligonucleotide Solved at 1.87 A Resolution, PDB code: 7zvn was solved by M.Hyjek-Skladanowska, B.Anderson, V.Mykhaylyk, C.Orr, A.Wagner, K.Skowronek, P.Seth, M.Nowotny, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.75 / 1.87
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	55.621, 57.502, 70.478, 90, 90.24, 90
R / Rfree (%)	16.7 / 19.8

The structure of Crystal Structure of Human Annexin A2 in Complex with Full Phosphorothioate 5-10 2'-Methoxyethyl Dna Gapmer Antisense Oligonucleotide Solved at 1.87 A Resolution also contains other interesting chemical elements:

Calcium

(Ca)

7 atoms

The binding sites of Magnesium atom in the Crystal Structure of Human Annexin A2 in Complex with Full Phosphorothioate 5-10 2'-Methoxyethyl Dna Gapmer Antisense Oligonucleotide Solved at 1.87 A Resolution (pdb code 7zvn). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Annexin A2 in Complex with Full Phosphorothioate 5-10 2'-Methoxyethyl Dna Gapmer Antisense Oligonucleotide Solved at 1.87 A Resolution, PDB code: 7zvn:

Magnesium binding site 1 out of 1 in the Crystal Structure of Human Annexin A2 in Complex with Full Phosphorothioate 5-10 2'-Methoxyethyl Dna Gapmer Antisense Oligonucleotide Solved at 1.87 A Resolution


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Annexin A2 in Complex with Full Phosphorothioate 5-10 2'-Methoxyethyl Dna Gapmer Antisense Oligonucleotide Solved at 1.87 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg416 b:40.9 occ:1.00 O A:HOH561 2.3 46.4 1.0 O A:HOH794 2.3 43.8 1.0 O A:HOH760 2.3 43.4 1.0 O A:HOH640 2.5 33.2 1.0 O A:HOH519 2.5 39.2 1.0 O A:HOH790 2.9 51.3 1.0 O A:HOH758 2.9 48.2 1.0 O A:HOH771 4.1 49.6 1.0 O A:TYR333 4.3 22.1 1.0 O A:HOH688 4.3 37.4 1.0 O A:THR61 4.6 24.5 1.0 OD1 A:ASN62 4.6 25.2 1.0 O A:HOH820 4.8 57.1 1.0 CA A:ASN62 5.0 22.2 1.0

M.Hyjek-Skladanowska, B.A.Anderson, V.Mykhaylyk, C.Orr, A.Wagner, J.T.Poznanski, K.Skowronek, P.Seth, M.Nowotny. Structures of Annexin A2-Ps Dna Complexes Show Dominance of Hydrophobic Interactions in Phosphorothioate Binding. Nucleic Acids Res. 2022.
ISSN: ESSN 1362-4962
PubMed: 36124719
DOI: 10.1093/NAR/GKAC774