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Atomistry » Magnesium » PDB 8ae7-8aq1 » 8afb » |
Magnesium in PDB 8afb: Crystal Structure of Kras-G12C in Complex with Compound 23 (Bi-0474)Enzymatic activity of Crystal Structure of Kras-G12C in Complex with Compound 23 (Bi-0474)
All present enzymatic activity of Crystal Structure of Kras-G12C in Complex with Compound 23 (Bi-0474):
3.6.5.2; Protein crystallography data
The structure of Crystal Structure of Kras-G12C in Complex with Compound 23 (Bi-0474), PDB code: 8afb
was solved by
J.Boettcher,
D.Kessler,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Kras-G12C in Complex with Compound 23 (Bi-0474)
(pdb code 8afb). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Kras-G12C in Complex with Compound 23 (Bi-0474), PDB code: 8afb: Magnesium binding site 1 out of 1 in 8afbGo back to Magnesium Binding Sites List in 8afb
Magnesium binding site 1 out
of 1 in the Crystal Structure of Kras-G12C in Complex with Compound 23 (Bi-0474)
Mono view Stereo pair view
Reference:
J.Broker,
A.G.Waterson,
C.Smethurst,
D.Kessler,
J.Bottcher,
M.Mayer,
G.Gmaschitz,
J.Phan,
A.Little,
J.R.Abbott,
Q.Sun,
M.Gmachl,
D.Rudolph,
H.Arnhof,
K.Rumpel,
F.Savarese,
T.Gerstberger,
N.Mischerikow,
M.Treu,
L.Herdeis,
T.Wunberg,
A.Gollner,
H.Weinstabl,
A.Mantoulidis,
O.Kramer,
D.B.Mcconnell,
S.W Fesik.
Fragment Optimization of Reversible Binding to the Switch II Pocket on Kras Leads to A Potent, in Vivo Active Kras G12C Inhibitor. J.Med.Chem. V. 65 14614 2022.
Page generated: Thu Oct 3 18:06:03 2024
ISSN: ISSN 0022-2623 PubMed: 36300829 DOI: 10.1021/ACS.JMEDCHEM.2C01120 |
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