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Atomistry » Magnesium » PDB 8aq5-8avq » 8atr » |
Magnesium in PDB 8atr: Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297)Enzymatic activity of Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297)
All present enzymatic activity of Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297):
2.7.11.1; Protein crystallography data
The structure of Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297), PDB code: 8atr
was solved by
E.J.Visser,
M.J.A.M.Overmans,
E.M.F.Vandenboorn,
C.Ottmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8atr:
The structure of Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297) also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297)
(pdb code 8atr). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297), PDB code: 8atr: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 8atrGo back to Magnesium Binding Sites List in 8atr
Magnesium binding site 1 out
of 2 in the Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297)
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 8atrGo back to Magnesium Binding Sites List in 8atr
Magnesium binding site 2 out
of 2 in the Small Molecular Stabilizer For C-Raf (PS259) and 14-3-3 (1075297)
Mono view Stereo pair view
Reference:
M.Konstantinidou,
E.J.Visser,
E.Vandenboorn,
S.Chen,
P.Jaishankar,
M.Overmans,
S.Dutta,
R.J.Neitz,
A.R.Renslo,
C.Ottmann,
L.Brunsveld,
M.R.Arkin.
Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 Sigma /Er Alpha Protein-Protein Interaction From Nonselective Fragments. J.Am.Chem.Soc. 2023.
Page generated: Thu Oct 3 18:44:16 2024
ISSN: ESSN 1520-5126 PubMed: 37676236 DOI: 10.1021/JACS.3C05161 |
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