Magnesium in PDB 8azr: Kras in Complex with Precursor 1

All present enzymatic activity of Kras in Complex with Precursor 1:
3.6.5.2;

The structure of Kras in Complex with Precursor 1, PDB code: 8azr was solved by J.Boettcher, L.Herdeis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.00 / 1.60
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.847, 40.3, 55.887, 90, 90, 90
R / Rfree (%)	17.9 / 23.2

The binding sites of Magnesium atom in the Kras in Complex with Precursor 1 (pdb code 8azr). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Kras in Complex with Precursor 1, PDB code: 8azr:

Magnesium binding site 1 out of 1 in the Kras in Complex with Precursor 1


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Kras in Complex with Precursor 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg202 b:7.3 occ:1.00 O A:HOH359 2.0 6.4 1.0 OG A:SER17 2.1 4.7 1.0 O2B A:GDP201 2.1 7.4 1.0 O A:HOH331 2.1 5.4 1.0 O A:HOH337 2.1 6.5 1.0 O A:HOH370 2.2 4.7 1.0 CB A:SER17 3.1 5.8 1.0 PB A:GDP201 3.3 7.0 1.0 O3B A:GDP201 3.6 7.8 1.0 N A:SER17 3.9 9.0 1.0 OD2 A:ASP57 4.0 5.7 1.0 CA A:SER17 4.1 5.9 1.0 O1A A:GDP201 4.1 8.5 1.0 OD1 A:ASP57 4.2 8.9 1.0 O A:PRO34 4.2 9.4 0.4 O A:PRO34 4.2 9.4 0.6 O3A A:GDP201 4.3 7.0 1.0 CA A:PRO34 4.3 10.1 0.6 CA A:PRO34 4.4 10.1 0.4 O1B A:GDP201 4.4 8.2 1.0 O A:ASP33 4.4 7.0 1.0 O A:ILE36 4.5 8.7 1.0 CG A:ASP57 4.5 6.0 1.0 PA A:GDP201 4.6 7.4 1.0 C A:PRO34 4.6 9.1 0.6 C A:PRO34 4.6 9.1 0.4 O A:THR58 4.6 7.3 1.0 O2A A:GDP201 4.7 8.0 1.0 CD2 A:TYR32 4.7 9.1 1.0 O A:TYR32 4.8 8.9 1.0 CB A:ALA59 4.8 7.1 1.0 C A:LYS16 5.0 6.7 1.0 CB A:LYS16 5.0 7.4 1.0

D.Kim, L.Herdeis, D.Rudolph, Y.Zhao, J.Bottcher, A.Vides, C.I.Ayala-Santos, Y.Pourfarjam, A.Cuevas-Navarro, J.Y.Xue, A.Mantoulidis, J.Broker, T.Wunberg, O.Schaaf, J.Popow, B.Wolkerstorfer, K.G.Kropatsch, R.Qu, E.De Stanchina, B.Sang, C.Li, D.B.Mcconnell, N.Kraut, P.Lito. Pan-Kras Inhibitor Disables Oncogenic Signalling and Tumour Growth. Nature 2023.
ISSN: ESSN 1476-4687
PubMed: 37258666
DOI: 10.1038/S41586-023-06123-3