Magnesium in PDB 8fc7: Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745

Enzymatic activity of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745

All present enzymatic activity of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745:
3.6.5.2;

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745 (pdb code 8fc7). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745, PDB code: 8fc7:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in 8fc7

Go back to Magnesium Binding Sites List in 8fc7
Magnesium binding site 1 out of 4 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Mg301

b:130.8
occ:1.00
 HG1 E:THR19 2.2 153.1 1.0
O E:THR37 2.2 153.4 1.0
O1B E:GDP302 2.3 162.5 1.0
OG1 E:THR19 2.4 153.1 1.0
HA E:THR37 2.7 153.4 1.0
C E:THR37 2.9 153.4 1.0
HB E:THR19 3.2 153.1 1.0
CB E:THR19 3.3 153.1 1.0
HG21 E:THR19 3.3 153.1 1.0
CA E:THR37 3.4 153.4 1.0
O E:PRO36 3.4 154.8 1.0
PB E:GDP302 3.7 162.5 1.0
O2A E:GDP302 3.7 162.5 1.0
HA E:VAL38 3.8 146.3 1.0
CG2 E:THR19 3.9 153.1 1.0
HB2 E:ALA61 3.9 158.0 1.0
N E:VAL38 3.9 146.3 1.0
O3B E:GDP302 4.0 162.5 1.0
H E:THR19 4.1 153.1 1.0
C E:PRO36 4.2 154.8 1.0
OG1 E:THR37 4.3 153.4 1.0
N E:THR37 4.3 153.4 1.0
HG12 E:VAL35 4.3 156.5 1.0
HG12 E:VAL38 4.4 146.3 1.0
HG23 E:THR19 4.4 153.1 1.0
HZ3 E:LYS18 4.4 156.0 1.0
CB E:THR37 4.4 153.4 1.0
CA E:VAL38 4.5 146.3 1.0
PA E:GDP302 4.6 162.5 1.0
O3A E:GDP302 4.6 162.5 1.0
O2B E:GDP302 4.6 162.5 1.0
CA E:THR19 4.6 153.1 1.0
OD2 E:ASP59 4.7 143.7 1.0
HG22 E:THR19 4.7 153.1 1.0
H E:VAL38 4.7 146.3 1.0
HG1 E:THR37 4.7 153.4 1.0
O1A E:GDP302 4.8 162.5 1.0
N E:THR19 4.8 153.1 1.0
HB1 E:ALA61 4.8 158.0 1.0
CB E:ALA61 4.8 158.0 1.0

Magnesium binding site 2 out of 4 in 8fc7

Go back to Magnesium Binding Sites List in 8fc7
Magnesium binding site 2 out of 4 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745 within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mg301

b:130.8
occ:1.00
 HG1 F:THR19 2.2 153.1 1.0
O F:THR37 2.2 153.4 1.0
O1B F:GDP302 2.3 162.5 1.0
OG1 F:THR19 2.4 153.1 1.0
HA F:THR37 2.7 153.4 1.0
C F:THR37 2.9 153.4 1.0
HB F:THR19 3.2 153.1 1.0
CB F:THR19 3.3 153.1 1.0
HG21 F:THR19 3.3 153.1 1.0
CA F:THR37 3.4 153.4 1.0
O F:PRO36 3.4 154.8 1.0
PB F:GDP302 3.7 162.5 1.0
O2A F:GDP302 3.7 162.5 1.0
HA F:VAL38 3.8 146.3 1.0
CG2 F:THR19 3.9 153.1 1.0
HB2 F:ALA61 3.9 158.0 1.0
N F:VAL38 3.9 146.3 1.0
O3B F:GDP302 4.0 162.5 1.0
H F:THR19 4.1 153.1 1.0
C F:PRO36 4.2 154.8 1.0
OG1 F:THR37 4.3 153.4 1.0
N F:THR37 4.3 153.4 1.0
HG12 F:VAL35 4.3 156.5 1.0
HG12 F:VAL38 4.4 146.3 1.0
HG23 F:THR19 4.4 153.1 1.0
HZ3 F:LYS18 4.4 156.0 1.0
CB F:THR37 4.5 153.4 1.0
CA F:VAL38 4.5 146.3 1.0
PA F:GDP302 4.6 162.5 1.0
O3A F:GDP302 4.6 162.5 1.0
O2B F:GDP302 4.6 162.5 1.0
CA F:THR19 4.6 153.1 1.0
OD2 F:ASP59 4.7 143.7 1.0
HG22 F:THR19 4.7 153.1 1.0
H F:VAL38 4.7 146.3 1.0
HG1 F:THR37 4.7 153.4 1.0
O1A F:GDP302 4.8 162.5 1.0
N F:THR19 4.8 153.1 1.0
HB1 F:ALA61 4.8 158.0 1.0
CB F:ALA61 4.8 158.0 1.0

Magnesium binding site 3 out of 4 in 8fc7

Go back to Magnesium Binding Sites List in 8fc7
Magnesium binding site 3 out of 4 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Mg301

b:130.8
occ:1.00
 HG1 G:THR19 2.2 153.1 1.0
O G:THR37 2.2 153.4 1.0
O1B G:GDP302 2.3 162.5 1.0
OG1 G:THR19 2.4 153.1 1.0
HA G:THR37 2.7 153.4 1.0
C G:THR37 2.9 153.4 1.0
HB G:THR19 3.2 153.1 1.0
CB G:THR19 3.3 153.1 1.0
HG21 G:THR19 3.3 153.1 1.0
CA G:THR37 3.4 153.4 1.0
O G:PRO36 3.4 154.8 1.0
PB G:GDP302 3.7 162.5 1.0
O2A G:GDP302 3.7 162.5 1.0
HA G:VAL38 3.8 146.3 1.0
CG2 G:THR19 3.9 153.1 1.0
HB2 G:ALA61 3.9 158.0 1.0
N G:VAL38 3.9 146.3 1.0
O3B G:GDP302 4.0 162.5 1.0
H G:THR19 4.1 153.1 1.0
C G:PRO36 4.2 154.8 1.0
OG1 G:THR37 4.3 153.4 1.0
N G:THR37 4.3 153.4 1.0
HG12 G:VAL35 4.3 156.5 1.0
HG12 G:VAL38 4.4 146.3 1.0
HG23 G:THR19 4.4 153.1 1.0
HZ3 G:LYS18 4.4 156.0 1.0
CB G:THR37 4.4 153.4 1.0
CA G:VAL38 4.5 146.3 1.0
PA G:GDP302 4.6 162.5 1.0
O3A G:GDP302 4.6 162.5 1.0
O2B G:GDP302 4.6 162.5 1.0
CA G:THR19 4.6 153.1 1.0
OD2 G:ASP59 4.7 143.7 1.0
HG22 G:THR19 4.7 153.1 1.0
H G:VAL38 4.7 146.3 1.0
HG1 G:THR37 4.7 153.4 1.0
O1A G:GDP302 4.8 162.5 1.0
N G:THR19 4.8 153.1 1.0
HB1 G:ALA61 4.8 158.0 1.0
CB G:ALA61 4.8 158.0 1.0

Magnesium binding site 4 out of 4 in 8fc7

Go back to Magnesium Binding Sites List in 8fc7
Magnesium binding site 4 out of 4 in the Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Cryo-Em Structure of the Human TRPV4 - Rhoa in Complex with GSK2798745 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Mg301

b:130.8
occ:1.00
 HG1 H:THR19 2.2 153.1 1.0
O H:THR37 2.2 153.4 1.0
O1B H:GDP302 2.3 162.5 1.0
OG1 H:THR19 2.4 153.1 1.0
HA H:THR37 2.7 153.4 1.0
C H:THR37 2.9 153.4 1.0
HB H:THR19 3.2 153.1 1.0
CB H:THR19 3.3 153.1 1.0
HG21 H:THR19 3.3 153.1 1.0
CA H:THR37 3.4 153.4 1.0
O H:PRO36 3.4 154.8 1.0
PB H:GDP302 3.7 162.5 1.0
O2A H:GDP302 3.7 162.5 1.0
HA H:VAL38 3.8 146.3 1.0
CG2 H:THR19 3.9 153.1 1.0
HB2 H:ALA61 3.9 158.0 1.0
N H:VAL38 3.9 146.3 1.0
O3B H:GDP302 4.0 162.5 1.0
H H:THR19 4.1 153.1 1.0
C H:PRO36 4.2 154.8 1.0
OG1 H:THR37 4.3 153.4 1.0
N H:THR37 4.3 153.4 1.0
HG12 H:VAL35 4.3 156.5 1.0
HG12 H:VAL38 4.4 146.3 1.0
HG23 H:THR19 4.4 153.1 1.0
HZ3 H:LYS18 4.4 156.0 1.0
CB H:THR37 4.4 153.4 1.0
CA H:VAL38 4.5 146.3 1.0
PA H:GDP302 4.6 162.5 1.0
O3A H:GDP302 4.6 162.5 1.0
O2B H:GDP302 4.6 162.5 1.0
CA H:THR19 4.6 153.1 1.0
OD2 H:ASP59 4.7 143.7 1.0
HG22 H:THR19 4.7 153.1 1.0
H H:VAL38 4.7 146.3 1.0
HG1 H:THR37 4.7 153.4 1.0
O1A H:GDP302 4.8 162.5 1.0
N H:THR19 4.8 153.1 1.0
HB1 H:ALA61 4.8 158.0 1.0
CB H:ALA61 4.8 158.0 1.0

Reference:

D.H.Kwon, F.Zhang, B.A.Mccray, S.Feng, M.Kumar, J.M.Sullivan, W.Im, C.J.Sumner, S.Y.Lee. TRPV4-Rho Gtpase Complex Structures Reveal Mechanisms of Gating and Disease. Nat Commun V. 14 3732 2023.
ISSN: ESSN 2041-1723
PubMed: 37353484
DOI: 10.1038/S41467-023-39345-0
Page generated: Thu Jul 27 23:48:36 2023

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy