Magnesium in PDB 8fzq: Dehosphorylated, Atp-Bound Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr)

All present enzymatic activity of Dehosphorylated, Atp-Bound Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr):
5.6.1.6;

The binding sites of Magnesium atom in the Dehosphorylated, Atp-Bound Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) (pdb code 8fzq). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Dehosphorylated, Atp-Bound Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr), PDB code: 8fzq:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Dehosphorylated, Atp-Bound Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Dehosphorylated, Atp-Bound Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1501 b:80.2 occ:1.00 O2B A:ATP1503 2.0 80.9 1.0 O3B A:ATP1503 2.1 80.9 1.0 OG1 A:THR465 2.3 76.9 1.0 O1G A:ATP1503 2.4 80.9 1.0 PG A:ATP1503 2.4 80.9 1.0 PB A:ATP1503 2.5 80.9 1.0 O3G A:ATP1503 2.7 80.9 1.0 OE1 A:GLN493 2.7 75.6 1.0 O2A A:ATP1503 3.2 80.9 1.0 CB A:THR465 3.3 76.9 1.0 O3A A:ATP1503 3.5 80.9 1.0 O1B A:ATP1503 3.7 80.9 1.0 CD A:GLN493 3.8 75.6 1.0 O2G A:ATP1503 3.9 80.9 1.0 N A:THR465 3.9 76.9 1.0 PA A:ATP1503 3.9 80.9 1.0 OD1 A:ASP572 4.2 81.0 1.0 CA A:THR465 4.2 76.9 1.0 CE A:LYS464 4.4 79.5 1.0 OD2 A:ASP572 4.4 81.0 1.0 NZ A:LYS464 4.4 79.5 1.0 NE2 A:GLN493 4.4 75.6 1.0 CG2 A:THR465 4.5 76.9 1.0 O1A A:ATP1503 4.6 80.9 1.0 CG A:ASP572 4.8 81.0 1.0 CG A:GLN493 4.9 75.6 1.0

Magnesium binding site 2 out of 2 in the Dehosphorylated, Atp-Bound Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Dehosphorylated, Atp-Bound Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1502 b:85.8 occ:1.00 O2B A:ATP1504 2.0 86.6 1.0 O3G A:ATP1504 2.0 86.6 1.0 OG A:SER1251 2.1 77.7 1.0 O3B A:ATP1504 2.3 86.6 1.0 PG A:ATP1504 2.4 86.6 1.0 PB A:ATP1504 2.6 86.6 1.0 OE1 A:GLN1291 2.7 75.5 1.0 O1G A:ATP1504 2.8 86.6 1.0 CB A:SER1251 3.4 77.7 1.0 CD A:GLN1291 3.5 75.5 1.0 O2A A:ATP1504 3.5 86.6 1.0 NE2 A:GLN1291 3.5 75.5 1.0 O3A A:ATP1504 3.6 86.6 1.0 N A:SER1251 3.7 77.7 1.0 NZ A:LYS1250 3.8 81.1 1.0 O1B A:ATP1504 3.8 86.6 1.0 O2G A:ATP1504 3.9 86.6 1.0 PA A:ATP1504 4.1 86.6 1.0 CA A:SER1251 4.1 77.7 1.0 CE A:LYS1250 4.3 81.1 1.0 O1A A:ATP1504 4.7 86.6 1.0 OE2 A:GLU1371 4.7 86.1 1.0 CB A:LYS1250 4.7 81.1 1.0 C A:LYS1250 4.8 81.1 1.0 OE1 A:GLU1371 4.9 86.1 1.0 CG A:GLN1291 4.9 75.5 1.0 N A:LYS1250 5.0 81.1 1.0

J.Levring, D.S.Terry, Z.Kilic, G.Fitzgerald, S.Blanchard, J.Chen. Cftr Function, Pathology and Pharmacology at Single-Molecule Resolution. Nature 2023.
ISSN: ESSN 1476-4687
PubMed: 36949202
DOI: 10.1038/S41586-023-05854-7