Magnesium in PDB 8gae: HSP90 Provides Platform For Craf Dephosphorylation By PP5

All present enzymatic activity of HSP90 Provides Platform For Craf Dephosphorylation By PP5:
2.7.11.1; 3.1.3.16;

The structure of HSP90 Provides Platform For Craf Dephosphorylation By PP5 also contains other interesting chemical elements:

Potassium	(K)	2 atoms
Manganese	(Mn)	2 atoms

The binding sites of Magnesium atom in the HSP90 Provides Platform For Craf Dephosphorylation By PP5 (pdb code 8gae). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the HSP90 Provides Platform For Craf Dephosphorylation By PP5, PDB code: 8gae:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the HSP90 Provides Platform For Craf Dephosphorylation By PP5


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of HSP90 Provides Platform For Craf Dephosphorylation By PP5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg802 b:124.9 occ:1.00 O2A A:ADP803 1.9 119.3 1.0 O2B A:ADP803 1.9 119.3 1.0 OD1 A:ASN46 1.9 120.8 1.0 CG A:ASN46 3.0 120.8 1.0 PA A:ADP803 3.0 119.3 1.0 HD21 A:ASN46 3.1 120.8 1.0 PB A:ADP803 3.1 119.3 1.0 O3A A:ADP803 3.4 119.3 1.0 ND2 A:ASN46 3.5 120.8 1.0 O5' A:ADP803 3.7 119.3 1.0 HA3 A:GLY132 3.9 112.9 1.0 HA2 A:GLY127 3.9 126.5 1.0 O3B A:ADP803 4.0 119.3 1.0 HA3 A:GLY127 4.0 126.5 1.0 HA A:ASN46 4.1 120.8 1.0 O1B A:ADP803 4.1 119.3 1.0 O1A A:ADP803 4.2 119.3 1.0 CB A:ASN46 4.3 120.8 1.0 HB2 A:SER45 4.4 119.0 1.0 HD22 A:ASN46 4.4 120.8 1.0 OE1 A:GLU42 4.5 118.6 1.0 CA A:GLY127 4.5 126.5 1.0 H A:ASN46 4.5 120.8 1.0 CA A:ASN46 4.6 120.8 1.0 O A:GLU42 4.6 118.6 1.0 HB3 A:GLU42 4.6 118.6 1.0 N A:ASN46 4.7 120.8 1.0 H A:PHE133 4.7 111.0 1.0 HB3 A:ASN46 4.7 120.8 1.0 HG1 A:THR110 4.7 130.1 1.0 H A:GLY132 4.8 112.9 1.0 OD1 A:ASP49 4.8 128.6 1.0 CA A:GLY132 4.9 112.9 1.0

Magnesium binding site 2 out of 2 in the HSP90 Provides Platform For Craf Dephosphorylation By PP5


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of HSP90 Provides Platform For Craf Dephosphorylation By PP5 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg802 b:132.7 occ:1.00 OD1 B:ASN46 1.9 117.6 1.0 O2A B:ATP803 2.0 122.1 1.0 O3G B:ATP803 2.0 122.1 1.0 O1B B:ATP803 2.0 122.1 1.0 CG B:ASN46 3.0 117.6 1.0 HD21 B:ASN46 3.0 117.6 1.0 PB B:ATP803 3.1 122.1 1.0 PA B:ATP803 3.1 122.1 1.0 PG B:ATP803 3.2 122.1 1.0 ND2 B:ASN46 3.3 117.6 1.0 O3A B:ATP803 3.5 122.1 1.0 O3B B:ATP803 3.6 122.1 1.0 O5' B:ATP803 3.8 122.1 1.0 HA3 B:GLY132 4.0 113.3 1.0 O2G B:ATP803 4.0 122.1 1.0 HA B:ASN46 4.1 117.6 1.0 HB2 B:SER45 4.2 115.8 1.0 O B:GLU42 4.2 117.3 1.0 CB B:ASN46 4.3 117.6 1.0 H B:ASN46 4.3 117.6 1.0 O1G B:ATP803 4.3 122.1 1.0 HD22 B:ASN46 4.3 117.6 1.0 O1A B:ATP803 4.3 122.1 1.0 O2B B:ATP803 4.4 122.1 1.0 HB3 B:GLU42 4.4 117.3 1.0 N B:ASN46 4.5 117.6 1.0 CA B:ASN46 4.5 117.6 1.0 H3' B:ATP803 4.5 122.1 1.0 OE1 B:GLU42 4.6 117.3 1.0 HB3 B:SER45 4.6 115.8 1.0 H B:PHE133 4.6 109.8 1.0 HA B:GLU42 4.7 117.3 1.0 H B:GLY132 4.7 113.3 1.0 HG22 B:ILE126 4.8 114.4 1.0 HA2 B:GLY127 4.8 124.2 1.0 HB3 B:ASN46 4.9 117.6 1.0 CB B:SER45 4.9 115.8 1.0 CA B:GLY132 4.9 113.3 1.0 HB2 B:ASN46 4.9 117.6 1.0 OD2 B:ASP49 5.0 120.8 1.0 HO3' B:ATP803 5.0 122.1 1.0

M.Jaime-Garza, D.A.Agard, C.A.Nowotny, C.Coutandin, F.Wang, M.Tabios. HSP90 Provides A Platform For Kinase Dephosphorylation By PP5 Nat Commun 2023.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-023-37659-7