Magnesium in PDB 8hbh: Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom

All present enzymatic activity of Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom:
4.6.1.2;

The structure of Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom also contains other interesting chemical elements:

Iron

(Fe)

1 atom

The binding sites of Magnesium atom in the Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom (pdb code 8hbh). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom, PDB code: 8hbh:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg701 b:46.6 occ:1.00 OD2 A:ASP530 2.0 38.3 1.0 OD1 A:ASP530 2.4 34.9 1.0 O5' B:G2P1001 2.5 41.2 1.0 CG A:ASP530 2.5 31.5 1.0 MG A:MG702 2.6 43.5 1.0 C3A B:G2P1001 2.7 37.1 1.0 PA B:G2P1001 3.0 51.9 1.0 OD2 A:ASP486 3.1 38.1 1.0 O1A B:G2P1001 3.6 41.7 1.0 C5' B:G2P1001 3.6 41.3 1.0 O3B B:G2P1001 3.8 46.2 1.0 CG A:ASP486 3.8 38.6 1.0 PB B:G2P1001 3.9 45.3 1.0 CB A:ASP530 4.0 24.4 1.0 O A:ILE487 4.3 40.9 1.0 CB A:ASP486 4.3 27.6 1.0 O2A B:G2P1001 4.4 51.8 1.0 OD1 A:ASP486 4.7 37.2 1.0 C3' B:G2P1001 4.7 44.3 1.0 C4' B:G2P1001 4.7 36.7 1.0 O2B B:G2P1001 4.7 39.2 1.0 CB A:PHE490 4.9 41.2 1.0 CA A:ASP530 4.9 26.5 1.0 N A:ILE487 5.0 34.8 1.0

Magnesium binding site 2 out of 2 in the Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of Human Soluble Guanylate Cyclase in the No-Activated State at 3.1 Angstrom within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg702 b:43.5 occ:1.00 O A:ILE487 2.2 40.9 1.0 MG A:MG701 2.6 46.6 1.0 O3B B:G2P1001 2.6 46.2 1.0 OD2 A:ASP530 2.7 38.3 1.0 C3A B:G2P1001 2.7 37.1 1.0 PB B:G2P1001 2.8 45.3 1.0 O1G B:G2P1001 2.9 42.2 1.0 O2B B:G2P1001 3.0 39.2 1.0 C A:ILE487 3.4 35.5 1.0 PG B:G2P1001 3.4 61.5 1.0 CG A:ASP530 3.8 31.5 1.0 CB A:ASP486 3.9 27.6 1.0 OD2 A:ASP486 3.9 38.1 1.0 N A:ILE487 4.0 34.8 1.0 PA B:G2P1001 4.1 51.9 1.0 O2G B:G2P1001 4.2 49.6 1.0 NH2 A:ARG574 4.2 36.1 1.0 N A:VAL488 4.3 36.5 1.0 CA A:ILE487 4.3 31.0 1.0 CA A:VAL488 4.3 42.8 1.0 OD1 A:ASP530 4.3 34.9 1.0 O1A B:G2P1001 4.3 41.7 1.0 CG A:ASP486 4.4 38.6 1.0 O1B B:G2P1001 4.4 42.0 1.0 N A:GLY489 4.4 40.8 1.0 O5' B:G2P1001 4.5 41.2 1.0 O3G B:G2P1001 4.5 44.5 1.0 CB A:PHE490 4.5 41.2 1.0 N A:PHE490 4.5 42.7 1.0 C A:ASP486 4.6 36.5 1.0 C A:VAL488 4.7 42.9 1.0 CA A:ASP486 4.8 25.6 1.0 NH1 A:ARG574 4.9 37.5 1.0 CB A:ASP530 4.9 24.4 1.0 CB A:ILE487 5.0 29.5 1.0

R.Liu, Y.Kang, L.Chen. No Binds to the Distal Site of Haem in the Fully Activated Soluble Guanylate Cyclase. Nitric Oxide V.-135 17 2023.
ISSN: ESSN 1089-8611
PubMed: 36972843
DOI: 10.1016/J.NIOX.2023.03.002