Magnesium in PDB 8ppk: Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit

All present enzymatic activity of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit:
4.2.99.18;

The structure of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit also contains other interesting chemical elements:

Zinc

(Zn)

3 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 40; Page 5, Binding sites: 41 - 50; Page 6, Binding sites: 51 - 60; Page 7, Binding sites: 61 - 70; Page 8, Binding sites: 71 - 80; Page 9, Binding sites: 81 - 90; Page 10, Binding sites: 91 - 100; Page 11, Binding sites: 101 - 110; Page 12, Binding sites: 111 - 111;

Binding sites:

The binding sites of Magnesium atom in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit (pdb code 8ppk). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 111 binding sites of Magnesium where determined in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit, PDB code: 8ppk:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Magnesium binding site 1 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1916 b:86.9 occ:1.00 OP1 2:U12 4.0 72.7 1.0 OP2 2:U12 4.1 65.7 1.0 O4 2:U9 4.1 77.8 1.0 P 2:U12 4.6 71.4 1.0 OP2 2:C13 4.9 68.1 1.0

Magnesium binding site 2 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1917 b:95.3 occ:1.00 OP2 2:A826 3.1 85.8 1.0 UNK 2:UNX2102 3.7 81.9 1.0 OP1 2:A825 4.1 77.3 1.0 P 2:A826 4.3 91.5 1.0 OP2 2:A825 4.5 80.2 1.0 N7 2:A827 4.5 83.0 1.0 O5' 2:A825 4.5 71.7 1.0 P 2:A825 4.5 88.3 1.0 O2 2:PSU822 4.6 76.9 1.0 OP1 2:A826 4.6 74.7 1.0 O4 2:U820 4.8 87.1 1.0

Magnesium binding site 3 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1918 b:51.5 occ:1.00 OP2 2:G1197 3.5 84.1 1.0 N7 2:G1197 3.6 69.5 1.0 OP2 2:A1196 3.9 99.1 1.0 O2' 2:U8 4.1 68.9 1.0 C8 2:G1197 4.1 73.9 1.0 O2 2:U8 4.6 83.5 1.0 C5 2:G1197 4.8 62.6 1.0 O5' 2:A1196 4.8 85.7 1.0 P 2:A1196 4.8 114.5 1.0 P 2:G1197 4.8 88.6 1.0 O5' 2:G1197 4.9 71.0 1.0

Magnesium binding site 4 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1919 b:72.6 occ:1.00 OP2 2:A1199 3.6 68.9 1.0 OP1 2:A1695 4.2 88.4 1.0 N7 2:A1199 4.3 63.7 1.0 N6 2:A1200 4.4 71.3 1.0 OP2 2:G1198 4.5 74.7 1.0 C8 2:A1199 4.7 62.4 1.0 N7 2:A1200 4.9 68.5 1.0 P 2:A1199 5.0 69.2 1.0

Magnesium binding site 5 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 5 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1920 b:97.2 occ:1.00 OP2 2:A1697 2.5 94.0 1.0 P 2:A1697 3.8 98.0 1.0 OP1 2:C1696 3.9 85.4 1.0 OP2 2:C1696 4.2 78.5 1.0 OP1 2:A1697 4.3 77.3 1.0 O5' 2:A1697 4.4 84.1 1.0 P 2:C1696 4.4 82.2 1.0 OP1 2:G10 4.5 67.5 1.0 O5' 2:C1696 4.8 79.8 1.0 O3' 2:U9 5.0 76.4 1.0 O3' 2:C1696 5.0 77.1 1.0

Magnesium binding site 6 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 6 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1921 b:61.7 occ:1.00 O6 2:G477 3.7 78.6 1.0 N7 2:A476 3.8 67.2 1.0 OP2 2:C475 3.9 74.4 1.0 C5 2:C475 4.0 62.1 1.0 C8 2:A476 4.0 65.1 1.0 N7 2:G477 4.1 82.6 1.0 C6 2:G477 4.4 77.6 1.0 C6 2:C475 4.4 69.7 1.0 OP2 2:A476 4.5 69.7 1.0 C5 2:G477 4.6 77.0 1.0 C4 2:C475 4.7 58.7 1.0 O2' 2:C472 4.8 73.0 1.0 O2 2:C472 4.8 71.3 1.0 N4 2:C475 4.9 74.4 1.0 O5' 2:C475 4.9 67.2 1.0 P 2:C475 5.0 72.1 1.0

Magnesium binding site 7 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 7 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1922 b:80.0 occ:1.00 OP2 2:A812 2.9 81.9 1.0 O2 2:C851 4.3 119.1 1.0 P 2:A812 4.4 99.7 1.0 N6 2:A813 4.4 71.1 1.0 N7 2:A812 4.6 72.5 1.0 N7 2:A813 4.8 64.1 1.0 C8 2:A812 4.9 70.0 1.0 O2 2:PSU814 4.9 74.4 1.0 O5' 2:A812 4.9 87.1 1.0

Magnesium binding site 8 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 8 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1923 b:86.8 occ:1.00 O6 2:G597 3.1 77.5 1.0 O4 2:U596 3.8 82.8 1.0 N7 2:G597 3.9 76.8 1.0 C6 2:G597 4.0 70.5 1.0 O6 2:G598 4.0 85.2 1.0 C5 2:G597 4.3 65.6 1.0 C4 2:U596 4.5 72.5 1.0 N7 2:G598 4.6 72.5 1.0 C6 2:G598 4.7 80.2 1.0 C5 2:U596 4.8 73.7 1.0 C5 2:G598 5.0 74.9 1.0

Magnesium binding site 9 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 9 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1924 b:65.6 occ:1.00 OP1 2:C632 4.2 88.4 1.0 OP2 2:C633 4.2 81.6 1.0 OP2 2:G598 4.4 81.7 1.0 OP2 2:A599 4.5 79.3 1.0

Magnesium binding site 10 out of 111 in the Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 10 of Bat-Hp-Cov NSP1 and EIF1 Bound to the Human 40S Small Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1925 b:87.3 occ:1.00 N7 2:A1080 4.3 74.4 1.0 OP2 2:C1032 4.4 69.4 1.0 O6 2:G1033 4.4 81.0 1.0 N6 2:A1080 4.6 76.6 1.0 OP2 2:A2M1031 4.8 88.8 1.0 C5 2:A1080 5.0 63.0 1.0

K.Schubert, E.D.Karousis, I.Ban, C.P.Lapointe, M.Leibundgut, E.Baumlin, E.Kummerant, A.Scaiola, T.Schonhut, J.Ziegelmuller, J.D.Puglisi, O.Muhlemann, N.Ban. Universal Features of NSP1-Mediated Translational Shutdown By Coronaviruses. Mol.Cell V. 83 3546 2023.
ISSN: ISSN 1097-2765
PubMed: 37802027
DOI: 10.1016/J.MOLCEL.2023.09.002