Magnesium in PDB 8v7z: Phosphorylated, Atp-Bound, E1371Q Human Cystic Fibrosis Transmembrane Conductance Regulator (E1371Q-Cftr)

All present enzymatic activity of Phosphorylated, Atp-Bound, E1371Q Human Cystic Fibrosis Transmembrane Conductance Regulator (E1371Q-Cftr):
5.6.1.6;

The binding sites of Magnesium atom in the Phosphorylated, Atp-Bound, E1371Q Human Cystic Fibrosis Transmembrane Conductance Regulator (E1371Q-Cftr) (pdb code 8v7z). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Phosphorylated, Atp-Bound, E1371Q Human Cystic Fibrosis Transmembrane Conductance Regulator (E1371Q-Cftr), PDB code: 8v7z:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Phosphorylated, Atp-Bound, E1371Q Human Cystic Fibrosis Transmembrane Conductance Regulator (E1371Q-Cftr)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Phosphorylated, Atp-Bound, E1371Q Human Cystic Fibrosis Transmembrane Conductance Regulator (E1371Q-Cftr) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1501 b:61.6 occ:1.00 OE1 A:GLN493 2.0 53.4 1.0 OG1 A:THR465 2.2 40.7 1.0 NE2 A:GLN493 2.2 52.3 1.0 O3G A:ATP1503 2.2 60.2 1.0 O2B A:ATP1503 2.2 62.2 1.0 CD A:GLN493 2.3 54.2 1.0 CB A:THR465 3.5 41.7 1.0 PB A:ATP1503 3.5 54.1 1.0 PG A:ATP1503 3.5 63.2 1.0 O3B A:ATP1503 3.6 54.7 1.0 CG A:GLN493 3.7 44.7 1.0 OD1 A:ASP572 3.8 66.6 1.0 CB A:GLN493 4.2 40.9 1.0 N A:THR465 4.3 38.1 1.0 O2G A:ATP1503 4.4 72.5 1.0 CG2 A:THR465 4.4 38.8 1.0 CA A:THR465 4.4 41.2 1.0 O1B A:ATP1503 4.4 73.8 1.0 O2A A:ATP1503 4.5 61.6 1.0 O3A A:ATP1503 4.5 44.4 1.0 O1G A:ATP1503 4.6 58.7 1.0 CG A:ASP572 4.6 59.6 1.0 NZ A:LYS464 4.7 60.5 1.0 OD2 A:ASP572 4.8 55.1 1.0 CE A:LYS464 4.8 46.9 1.0 CB A:HIS1348 4.9 47.0 1.0

Magnesium binding site 2 out of 2 in the Phosphorylated, Atp-Bound, E1371Q Human Cystic Fibrosis Transmembrane Conductance Regulator (E1371Q-Cftr)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Phosphorylated, Atp-Bound, E1371Q Human Cystic Fibrosis Transmembrane Conductance Regulator (E1371Q-Cftr) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1502 b:29.5 occ:1.00 OE1 A:GLN1291 2.0 54.6 1.0 OG A:SER1251 2.0 46.4 1.0 O3G A:ATP1504 2.3 60.3 1.0 CD A:GLN1291 2.8 52.8 1.0 O2B A:ATP1504 3.0 48.8 1.0 NE2 A:GLN1291 3.1 50.0 1.0 O3B A:ATP1504 3.1 44.0 1.0 CB A:SER1251 3.2 44.4 1.0 PG A:ATP1504 3.3 62.9 1.0 PB A:ATP1504 3.6 39.7 1.0 O3A A:ATP1504 3.9 40.9 1.0 OD1 A:ASP1370 4.1 59.9 1.0 O1G A:ATP1504 4.1 64.1 1.0 N A:SER1251 4.2 48.3 1.0 CG A:GLN1291 4.2 50.9 1.0 CA A:SER1251 4.2 43.0 1.0 NZ A:LYS1250 4.4 51.6 1.0 O2G A:ATP1504 4.5 48.5 1.0 OD2 A:ASP1370 4.7 52.8 1.0 CB A:GLN1291 4.8 50.1 1.0 CE A:LYS1250 4.8 42.6 1.0 CG A:ASP1370 4.8 58.6 1.0 N A:GLY550 4.9 39.5 1.0 CB A:SER549 4.9 49.4 1.0 O1B A:ATP1504 5.0 56.1 1.0

X.Gao, H.Yeh, Z.Yang, C.Fan, F.Jiang, R.J.Howard, E.Lindahl, J.C.Kappes, T.Hwang. Allosteric Inhibition of Cftr Gating By Cftrinh-172 Binding in the Pore Nat Commun 2024.
ISSN: ESSN 2041-1723