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Magnesium in PDB 8xwc: Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K

Enzymatic activity of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K

All present enzymatic activity of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K:
4.2.99.18;

Protein crystallography data

The structure of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K, PDB code: 8xwc was solved by M.Unno, M.Koga, N.Minowa, S.Komuro, Y.Tanaka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.98 / 1.45
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 61.808, 69.544, 87.955, 90, 90, 90
R / Rfree (%) 15.4 / 17.9

Other elements in 8xwc:

The structure of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K also contains other interesting chemical elements:

Sodium (Na) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K (pdb code 8xwc). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K, PDB code: 8xwc:

Magnesium binding site 1 out of 1 in 8xwc

Go back to Magnesium Binding Sites List in 8xwc
Magnesium binding site 1 out of 1 in the Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg403

b:14.5
occ:1.00
 O A:HOH753 2.2 26.7 1.0
O A:LEU243 2.4 11.2 1.0
O A:CYS241 2.4 11.7 1.0
O A:VAL246 2.4 10.4 1.0
O C:HOH116 2.5 29.9 1.0
OP1 C:DC28 2.8 15.7 1.0
C A:LEU243 3.4 10.3 1.0
C A:CYS241 3.4 10.1 1.0
C A:VAL246 3.5 10.0 1.0
OP2 C:DC28 3.6 15.2 1.0
P C:DC28 3.7 14.1 1.0
N A:LEU243 3.8 9.0 1.0
N A:VAL246 3.9 9.4 1.0
C A:ILE242 3.9 10.1 1.0
O A:HOH748 4.1 35.6 1.0
O C:HOH117 4.1 20.4 1.0
CA A:VAL246 4.1 10.0 1.0
CA A:CYS241 4.1 10.0 1.0
O A:ILE242 4.2 11.9 1.0
CA A:LEU243 4.2 10.0 1.0
N A:PRO244 4.2 9.8 1.0
CA A:PRO244 4.3 12.0 1.0
N A:ILE242 4.4 10.4 1.0
N A:GLY245 4.4 10.9 1.0
CB A:VAL246 4.4 8.7 1.0
CA A:ILE242 4.5 10.6 1.0
N A:GLY247 4.5 9.0 1.0
O3' C:DT27 4.6 12.9 1.0
C A:PRO244 4.7 12.9 1.0
O A:LEU240 4.8 10.0 1.0
CB A:CYS241 4.8 10.0 1.0
C A:GLY245 4.9 9.7 1.0
CA A:GLY247 4.9 8.7 1.0
O5' C:DC28 5.0 15.7 1.0

Reference:

M.Unno, M.Morikawa, V.Sychovsky, M.Koga, N.Minowa, S.Komuro, M.Fukuta, F.Tshuyuguchi, R.Inamura, H.Mano, K.Nakashima, Y.Okamoto, T.Saito, Y.Hattori, Y.Tanaka. Active Residue Mutation of HOGG1 Provides A Novel Active Mutant with An Alternative Reaction Pathway To Be Published.
Page generated: Fri Aug 15 21:14:08 2025

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