Magnesium in PDB 8zrx: Structure of Human ECHS1 in Complex with Acetoacetyl-Coa

All present enzymatic activity of Structure of Human ECHS1 in Complex with Acetoacetyl-Coa:
4.2.1.17; 5.3.3.8;

The binding sites of Magnesium atom in the Structure of Human ECHS1 in Complex with Acetoacetyl-Coa (pdb code 8zrx). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of Human ECHS1 in Complex with Acetoacetyl-Coa, PDB code: 8zrx:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of Human ECHS1 in Complex with Acetoacetyl-Coa


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Human ECHS1 in Complex with Acetoacetyl-Coa within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg302 b:87.7 occ:1.00 O A:ALA206 3.4 80.4 1.0 O C:ALA206 3.7 80.4 1.0 O B:ALA206 3.8 80.4 1.0 C A:ALA206 4.3 80.1 1.0 HA A:ALA206 4.4 80.1 1.0 O A:GLN205 4.5 80.4 1.0 HA B:ALA206 4.5 80.1 1.0 HA C:ALA206 4.5 80.1 1.0 C C:ALA206 4.5 80.1 1.0 C B:ALA206 4.5 80.1 1.0 HA3 A:GLY207 4.6 79.9 1.0 O A:ALA182 4.7 76.4 1.0 HA3 C:GLY207 4.7 79.9 1.0 O B:GLN205 4.8 80.4 1.0 O C:GLN205 4.8 80.4 1.0 HA3 B:GLY207 4.8 79.9 1.0 CA A:ALA206 4.9 80.1 1.0 O C:ALA182 4.9 76.4 1.0 O B:ALA182 5.0 76.4 1.0

Magnesium binding site 2 out of 2 in the Structure of Human ECHS1 in Complex with Acetoacetyl-Coa


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of Human ECHS1 in Complex with Acetoacetyl-Coa within 5.0Å range: probe atom residue distance (Å) B Occ D:Mg302 b:87.7 occ:1.00 O E:ALA206 3.2 80.4 1.0 O D:ALA206 3.5 80.4 1.0 O F:ALA206 3.8 80.4 1.0 C E:ALA206 4.3 80.1 1.0 HA E:ALA206 4.3 80.1 1.0 C D:ALA206 4.4 80.1 1.0 HA D:ALA206 4.4 80.1 1.0 C F:ALA206 4.5 80.1 1.0 HA F:ALA206 4.5 80.1 1.0 HA3 F:GLY207 4.6 79.9 1.0 HA3 D:GLY207 4.7 79.9 1.0 O E:ALA182 4.7 76.4 1.0 HA3 E:GLY207 4.7 79.9 1.0 O E:GLN205 4.7 80.4 1.0 O D:GLN205 4.8 80.4 1.0 O F:GLN205 4.8 80.4 1.0 CA E:ALA206 4.9 80.1 1.0 O D:ALA182 5.0 76.4 1.0 CA D:ALA206 5.0 80.1 1.0 O F:ALA182 5.0 76.4 1.0

G.Su, Y.Xu, B.Chen, K.Ju, Y.Jin, H.Chen, S.Zhang, X.Luan. Structural and Biochemical Mechanism of Short-Chain Enoyl-Coa Hydratase (ECHS1) Substrate Recognition. Commun Biol V. 8 619 2025.
ISSN: ESSN 2399-3642
PubMed: 40240482
DOI: 10.1038/S42003-025-07924-0