Magnesium in PDB 9bpd: Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+

The binding sites of Magnesium atom in the Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+ (pdb code 9bpd). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+, PDB code: 9bpd:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg402 b:171.2 occ:1.00 O3B C:ATP401 2.0 137.7 1.0 O3G C:ATP401 2.1 135.9 1.0 OD2 A:ASP153 2.5 169.1 1.0 PG C:ATP401 2.6 136.2 1.0 PB C:ATP401 2.8 147.1 1.0 O1B C:ATP401 2.9 137.9 1.0 O2B C:ATP401 3.2 137.0 1.0 O2G C:ATP401 3.4 136.7 1.0 CG A:ASP153 3.7 169.7 1.0 O1G C:ATP401 3.8 132.0 1.0 O3A C:ATP401 4.2 138.6 1.0 OD1 A:ASP153 4.3 169.5 1.0 CB A:ASP153 4.7 168.8 1.0 NH2 A:ARG276 4.8 109.4 1.0

Magnesium binding site 2 out of 3 in the Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg402 b:171.2 occ:1.00 O3B A:ATP403 2.0 137.7 1.0 O3G A:ATP403 2.1 135.9 1.0 OD2 B:ASP153 2.5 169.1 1.0 PG A:ATP403 2.6 136.2 1.0 PB A:ATP403 2.8 147.1 1.0 O1B A:ATP403 2.9 137.9 1.0 O2B A:ATP403 3.2 137.0 1.0 O2G A:ATP403 3.4 136.7 1.0 CG B:ASP153 3.7 169.7 1.0 O1G A:ATP403 3.8 132.0 1.0 O3A A:ATP403 4.2 138.6 1.0 OD1 B:ASP153 4.3 169.5 1.0 CB B:ASP153 4.7 168.8 1.0 NH2 B:ARG276 4.8 109.4 1.0

Magnesium binding site 3 out of 3 in the Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Cryo-Em Structure of P2X3 Receptor in Complex with Atp:MG2+ within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg403 b:171.2 occ:1.00 O3B B:ATP403 2.0 137.7 1.0 O3G B:ATP403 2.1 135.9 1.0 OD2 C:ASP153 2.5 169.1 1.0 PG B:ATP403 2.6 136.2 1.0 PB B:ATP403 2.8 147.1 1.0 O1B B:ATP403 2.9 137.9 1.0 O2B B:ATP403 3.2 137.0 1.0 O2G B:ATP403 3.4 136.7 1.0 CG C:ASP153 3.7 169.7 1.0 O1G B:ATP403 3.8 132.0 1.0 O3A B:ATP403 4.2 138.6 1.0 OD1 C:ASP153 4.3 169.5 1.0 CB C:ASP153 4.7 168.8 1.0 NH2 C:ARG276 4.8 109.4 1.0

T.Thach, K.Dhanabalan, P.P.Nandekar, S.Stauffer, I.Heisler, S.Alvarado, J.Snyder, R.Subramanian. Mechanistic Insights Into the Selective Targeting of P2X3 Receptor By Camlipixant Antagonist. J.Biol.Chem. V. 301 08109 2025.
ISSN: ESSN 1083-351X
PubMed: 39706278
DOI: 10.1016/J.JBC.2024.108109