Magnesium in PDB 9f07: Tubulin:Stathmin:Darpin:Tau MTBR3 Complex

The structure of Tubulin:Stathmin:Darpin:Tau MTBR3 Complex, PDB code: 9f07 was solved by L.Ammar Khodja, V.Campanacci, B.Gigant, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	159.03 / 2.21
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	52.298, 222.25, 227.657, 90, 90, 90
R / Rfree (%)	20 / 23.4

The binding sites of Magnesium atom in the Tubulin:Stathmin:Darpin:Tau MTBR3 Complex (pdb code 9f07). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Tubulin:Stathmin:Darpin:Tau MTBR3 Complex, PDB code: 9f07:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Tubulin:Stathmin:Darpin:Tau MTBR3 Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Tubulin:Stathmin:Darpin:Tau MTBR3 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg502 b:27.3 occ:1.00 O A:HOH617 1.9 16.1 1.0 O1B A:GTP501 2.0 27.2 1.0 O1G A:GTP501 2.2 24.4 1.0 O A:HOH629 2.2 19.2 1.0 O A:HOH603 2.4 30.3 1.0 O A:HOH630 2.4 17.6 1.0 PB A:GTP501 3.1 27.1 1.0 PG A:GTP501 3.1 24.7 1.0 O3B A:GTP501 3.3 25.7 1.0 O2G A:GTP501 3.4 25.0 1.0 O3A A:GTP501 3.6 27.6 1.0 NZ B:LYS254 3.9 20.7 1.0 OD2 A:ASP69 4.0 45.4 1.0 CB A:GLN11 4.1 31.9 1.0 N A:GLN11 4.3 31.5 1.0 OD1 A:ASP69 4.3 43.8 1.0 OE2 A:GLU71 4.4 47.5 1.0 O2B A:GTP501 4.4 27.5 1.0 O1A A:GTP501 4.5 27.6 1.0 CG A:GLU71 4.5 43.7 1.0 O3G A:GTP501 4.5 24.9 1.0 CB A:ASP98 4.5 35.1 1.0 O A:HOH619 4.5 40.2 1.0 OD2 A:ASP98 4.6 37.7 1.0 PA A:GTP501 4.6 28.1 1.0 CG A:ASP69 4.6 44.3 1.0 CA A:GLN11 4.8 31.5 1.0 OE1 A:GLN11 4.8 41.9 1.0 CG A:ASP98 4.8 35.4 1.0 CD A:GLU71 4.9 46.3 1.0 OG1 A:THR145 5.0 28.3 1.0

Magnesium binding site 2 out of 2 in the Tubulin:Stathmin:Darpin:Tau MTBR3 Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Tubulin:Stathmin:Darpin:Tau MTBR3 Complex within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg502 b:23.1 occ:1.00 O1B E:GTP501 2.0 28.1 1.0 O E:HOH612 2.1 26.4 1.0 O E:HOH646 2.2 27.3 1.0 O E:HOH614 2.2 21.2 1.0 O1G E:GTP501 2.2 27.5 1.0 O E:HOH618 2.4 19.4 1.0 PB E:GTP501 3.1 28.2 1.0 PG E:GTP501 3.1 27.8 1.0 O3B E:GTP501 3.3 27.9 1.0 O2G E:GTP501 3.4 27.9 1.0 O3A E:GTP501 3.6 28.0 1.0 NZ F:LYS254 4.0 20.3 1.0 OD2 E:ASP69 4.0 36.7 1.0 CB E:GLN11 4.1 26.4 1.0 OD1 E:ASP69 4.3 36.0 1.0 N E:GLN11 4.3 24.9 1.0 OE2 E:GLU71 4.4 40.6 1.0 O2B E:GTP501 4.4 28.4 1.0 CG E:GLU71 4.5 38.5 1.0 O1A E:GTP501 4.5 28.2 1.0 CB E:ASP98 4.5 31.8 1.0 O3G E:GTP501 4.5 27.1 1.0 O E:HOH609 4.5 40.8 1.0 OD2 E:ASP98 4.6 33.9 1.0 CG E:ASP69 4.6 36.2 1.0 PA E:GTP501 4.6 27.9 1.0 CA E:GLN11 4.8 25.4 1.0 OE1 E:GLN11 4.8 33.1 1.0 CG E:ASP98 4.8 33.0 1.0 CD E:GLU71 5.0 40.3 1.0 OG1 E:THR145 5.0 27.8 1.0

L.A.Khodja, V.Campanacci, G.Lippens, B.Gigant. The Structure of A Tau Fragment Bound to Tubulin Prompts New Hypotheses on Tau Mechanism and Oligomerization PNAS Nexus 2024.
ISSN: ESSN 2752-6542
DOI: 10.1093/PNASNEXUS/PGAE487