Magnesium in PDB 9hiy: Cryo-Em Structure of Cak (CDK7 D97N Mutant) in Complex with Atpgs

All present enzymatic activity of Cryo-Em Structure of Cak (CDK7 D97N Mutant) in Complex with Atpgs:
2.7.11.22; 2.7.11.23;

The binding sites of Magnesium atom in the Cryo-Em Structure of Cak (CDK7 D97N Mutant) in Complex with Atpgs (pdb code 9hiy). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Cryo-Em Structure of Cak (CDK7 D97N Mutant) in Complex with Atpgs, PDB code: 9hiy:

Magnesium binding site 1 out of 1 in the Cryo-Em Structure of Cak (CDK7 D97N Mutant) in Complex with Atpgs


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of Cak (CDK7 D97N Mutant) in Complex with Atpgs within 5.0Å range: probe atom residue distance (Å) B Occ J:Mg402 b:48.2 occ:1.00 OD1 J:ASN142 2.5 40.4 1.0 OD2 J:ASP155 2.9 57.1 1.0 O3A J:AGS401 3.4 84.5 1.0 CG J:ASN142 3.6 31.9 1.0 O1B J:AGS401 3.6 102.3 1.0 CG J:ASP155 3.6 51.9 1.0 S1G J:AGS401 4.0 129.8 1.0 PB J:AGS401 4.0 98.3 1.0 ND2 J:ASN142 4.0 34.9 1.0 O2A J:AGS401 4.1 79.4 1.0 CB J:ASP155 4.1 33.2 1.0 OD1 J:ASN141 4.3 42.4 1.0 PA J:AGS401 4.4 84.1 1.0 OD1 J:ASP155 4.4 53.6 1.0 O3B J:AGS401 4.5 88.6 1.0 CE J:LYS139 4.6 39.7 1.0 CG J:ASN141 4.6 41.2 1.0 ND2 J:ASN141 4.8 44.2 1.0 OD2 J:ASP137 4.8 50.5 1.0 CB J:ASN142 4.8 26.8 1.0 O J:ASN141 4.8 37.9 1.0 CA J:ASN142 4.9 26.3 1.0

C.-F.Lai, V.I.Cushing, C.L.Bevan, R.C.Coombes, B.J.Greber, L.Buluwela, S.Ali. Mutation of CDK7 at A Conserved Residue Identifies A Common Mechanism of Acquired Resistance to Cdk Inhibitors in Cancer To Be Published.