Magnesium in PDB 9iqx: Cryo-Em Structure of the Human TRPV4-Rhoa in Complex with AH001

All present enzymatic activity of Cryo-Em Structure of the Human TRPV4-Rhoa in Complex with AH001:
3.6.5.2;

The binding sites of Magnesium atom in the Cryo-Em Structure of the Human TRPV4-Rhoa in Complex with AH001 (pdb code 9iqx). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cryo-Em Structure of the Human TRPV4-Rhoa in Complex with AH001, PDB code: 9iqx:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cryo-Em Structure of the Human TRPV4-Rhoa in Complex with AH001


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the Human TRPV4-Rhoa in Complex with AH001 within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg202 b:62.7 occ:1.00 O E:THR37 2.1 66.8 1.0 O1B E:GDP201 2.1 69.7 1.0 OG1 E:THR19 2.2 62.2 1.0 PB E:GDP201 3.0 69.7 1.0 C E:THR37 3.3 66.8 1.0 O2B E:GDP201 3.3 69.7 1.0 CB E:THR19 3.4 62.2 1.0 O3B E:GDP201 3.7 69.7 1.0 CA E:THR37 4.1 66.8 1.0 OD1 E:ASP59 4.1 58.1 1.0 N E:THR19 4.1 62.2 1.0 N E:VAL38 4.3 63.6 1.0 O E:PRO36 4.3 69.6 1.0 CA E:THR19 4.4 62.2 1.0 O3A E:GDP201 4.4 69.7 1.0 CG2 E:THR19 4.5 62.2 1.0 CA E:VAL38 4.5 63.6 1.0 OD2 E:ASP59 4.5 58.1 1.0 CE E:LYS18 4.5 62.3 1.0 CG2 E:THR37 4.6 66.8 1.0 CG E:ASP59 4.6 58.1 1.0 O E:THR60 4.7 58.8 1.0 CB E:ALA61 4.8 64.6 1.0 NZ E:LYS18 4.8 62.3 1.0 CB E:LYS18 4.8 62.3 1.0 CG1 E:VAL38 4.9 63.6 1.0 O1A E:GDP201 4.9 69.7 1.0 PA E:GDP201 5.0 69.7 1.0 O2A E:GDP201 5.0 69.7 1.0 CB E:THR37 5.0 66.8 1.0

Magnesium binding site 2 out of 2 in the Cryo-Em Structure of the Human TRPV4-Rhoa in Complex with AH001


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of the Human TRPV4-Rhoa in Complex with AH001 within 5.0Å range: probe atom residue distance (Å) B Occ F:Mg202 b:62.7 occ:1.00 O F:THR37 2.1 66.8 1.0 O1B F:GDP201 2.1 69.7 1.0 OG1 F:THR19 2.2 62.2 1.0 PB F:GDP201 3.0 69.7 1.0 C F:THR37 3.3 66.8 1.0 O2B F:GDP201 3.3 69.7 1.0 CB F:THR19 3.4 62.2 1.0 O3B F:GDP201 3.7 69.7 1.0 CA F:THR37 4.1 66.8 1.0 OD1 F:ASP59 4.1 58.1 1.0 N F:THR19 4.1 62.2 1.0 N F:VAL38 4.3 63.6 1.0 O F:PRO36 4.3 69.6 1.0 CA F:THR19 4.4 62.2 1.0 O3A F:GDP201 4.4 69.7 1.0 CG2 F:THR19 4.5 62.2 1.0 CA F:VAL38 4.5 63.6 1.0 OD2 F:ASP59 4.5 58.1 1.0 CE F:LYS18 4.5 62.3 1.0 CG2 F:THR37 4.6 66.8 1.0 CG F:ASP59 4.6 58.1 1.0 O F:THR60 4.7 58.8 1.0 CB F:ALA61 4.8 64.6 1.0 NZ F:LYS18 4.8 62.3 1.0 CB F:LYS18 4.8 62.3 1.0 CG1 F:VAL38 4.9 63.6 1.0 O1A F:GDP201 4.9 69.7 1.0 PA F:GDP201 5.0 69.7 1.0 O2A F:GDP201 5.0 69.7 1.0 CB F:THR37 5.0 66.8 1.0

J.W.Wang, Z.Yuan. Inactivation of Rhoa For Hypertension Treatment Through A TRPV4-Rhoa-RHOGDI1 Axis To Be Published.